Recent advances in the development of liquid crystalline nanoparticles as drug delivery systems

Due to their distinctive structural features, lyotropic nonlamellar liquid crystalline nanoparticles (LCNPs), such as cubosomes and hexosomes, are considered effective drug delivery systems. Cubosomes have a lipid bilayer that makes a membrane lattice with two water channels that are intertwined. He...

Full description

Saved in:
Bibliographic Details
Main Authors: Leu, Jassica S. L., Teoh, Jasy J. X., Ling, Angel L. Q., Chong, Joey, Loo, Yan Shan, Mat Azmi, Intan Diana, Zahid, Noor Idayu, Bose, Rajendran J. C., Madheswaran, Thiagarajan
Format: Article
Language:English
Published: Multidisciplinary Digital Publishing Institute 2023
Online Access:http://psasir.upm.edu.my/id/eprint/109442/1/pharmaceutics-15-01421.pdf
http://psasir.upm.edu.my/id/eprint/109442/
https://www.mdpi.com/1999-4923/15/5/1421
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.upm.eprints.109442
record_format eprints
spelling my.upm.eprints.1094422024-12-10T03:02:12Z http://psasir.upm.edu.my/id/eprint/109442/ Recent advances in the development of liquid crystalline nanoparticles as drug delivery systems Leu, Jassica S. L. Teoh, Jasy J. X. Ling, Angel L. Q. Chong, Joey Loo, Yan Shan Mat Azmi, Intan Diana Zahid, Noor Idayu Bose, Rajendran J. C. Madheswaran, Thiagarajan Due to their distinctive structural features, lyotropic nonlamellar liquid crystalline nanoparticles (LCNPs), such as cubosomes and hexosomes, are considered effective drug delivery systems. Cubosomes have a lipid bilayer that makes a membrane lattice with two water channels that are intertwined. Hexosomes are inverse hexagonal phases made of an infinite number of hexagonal lattices that are tightly connected with water channels. These nanostructures are often stabilized by surfactants. The structure’s membrane has a much larger surface area than that of other lipid nanoparticles, which makes it possible to load therapeutic molecules. In addition, the composition of mesophases can be modified by pore diameters, thus influencing drug release. Much research has been conducted in recent years to improve their preparation and characterization, as well as to control drug release and improve the efficacy of loaded bioactive chemicals. This article reviews current advances in LCNP technology that permit their application, as well as design ideas for revolutionary biomedical applications. Furthermore, we have provided a summary of the application of LCNPs based on the administration routes, including the pharmacokinetic modulation property. Multidisciplinary Digital Publishing Institute 2023-05-06 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/109442/1/pharmaceutics-15-01421.pdf Leu, Jassica S. L. and Teoh, Jasy J. X. and Ling, Angel L. Q. and Chong, Joey and Loo, Yan Shan and Mat Azmi, Intan Diana and Zahid, Noor Idayu and Bose, Rajendran J. C. and Madheswaran, Thiagarajan (2023) Recent advances in the development of liquid crystalline nanoparticles as drug delivery systems. Pharmaceutics, 15 (5). pp. 1-26. ISSN 1999-4923 https://www.mdpi.com/1999-4923/15/5/1421 10.3390/pharmaceutics15051421
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Due to their distinctive structural features, lyotropic nonlamellar liquid crystalline nanoparticles (LCNPs), such as cubosomes and hexosomes, are considered effective drug delivery systems. Cubosomes have a lipid bilayer that makes a membrane lattice with two water channels that are intertwined. Hexosomes are inverse hexagonal phases made of an infinite number of hexagonal lattices that are tightly connected with water channels. These nanostructures are often stabilized by surfactants. The structure’s membrane has a much larger surface area than that of other lipid nanoparticles, which makes it possible to load therapeutic molecules. In addition, the composition of mesophases can be modified by pore diameters, thus influencing drug release. Much research has been conducted in recent years to improve their preparation and characterization, as well as to control drug release and improve the efficacy of loaded bioactive chemicals. This article reviews current advances in LCNP technology that permit their application, as well as design ideas for revolutionary biomedical applications. Furthermore, we have provided a summary of the application of LCNPs based on the administration routes, including the pharmacokinetic modulation property.
format Article
author Leu, Jassica S. L.
Teoh, Jasy J. X.
Ling, Angel L. Q.
Chong, Joey
Loo, Yan Shan
Mat Azmi, Intan Diana
Zahid, Noor Idayu
Bose, Rajendran J. C.
Madheswaran, Thiagarajan
spellingShingle Leu, Jassica S. L.
Teoh, Jasy J. X.
Ling, Angel L. Q.
Chong, Joey
Loo, Yan Shan
Mat Azmi, Intan Diana
Zahid, Noor Idayu
Bose, Rajendran J. C.
Madheswaran, Thiagarajan
Recent advances in the development of liquid crystalline nanoparticles as drug delivery systems
author_facet Leu, Jassica S. L.
Teoh, Jasy J. X.
Ling, Angel L. Q.
Chong, Joey
Loo, Yan Shan
Mat Azmi, Intan Diana
Zahid, Noor Idayu
Bose, Rajendran J. C.
Madheswaran, Thiagarajan
author_sort Leu, Jassica S. L.
title Recent advances in the development of liquid crystalline nanoparticles as drug delivery systems
title_short Recent advances in the development of liquid crystalline nanoparticles as drug delivery systems
title_full Recent advances in the development of liquid crystalline nanoparticles as drug delivery systems
title_fullStr Recent advances in the development of liquid crystalline nanoparticles as drug delivery systems
title_full_unstemmed Recent advances in the development of liquid crystalline nanoparticles as drug delivery systems
title_sort recent advances in the development of liquid crystalline nanoparticles as drug delivery systems
publisher Multidisciplinary Digital Publishing Institute
publishDate 2023
url http://psasir.upm.edu.my/id/eprint/109442/1/pharmaceutics-15-01421.pdf
http://psasir.upm.edu.my/id/eprint/109442/
https://www.mdpi.com/1999-4923/15/5/1421
_version_ 1818835872256098304
score 13.222552