Toxicity and teratogenicity effects of valproic acid on zebrafish (Danio rerio) embryos in relation to autism spectrum disorder

• Main Authors: Saleh Hodin, Nur Atikah, Chong, Siok Geok, Abu Bakar, Noraini, Mohd Fahmi, Muhammad Syafiq Akmal, Ramlan, Nurul Farhana, Zulkifli Hamid, Nik Nur Aini Zulaikha, Mohd Fadzar, Muhammad Syuqor Iqbal, Zulkifli, Abdul Rahman, Norazhar, Anis Irfan, Mastuki, Siti Nurulhuda, Mohd Faudzi, Siti Munirah, Wan Ibrahim, Wan Norhamidah, Azmai, Mohammad Noor Amal
• Format: Article
• Published: John Wiley 2023
• Online Access: http://psasir.upm.edu.my/id/eprint/108327/; https://onlinelibrary.wiley.com/doi/10.1002/bdr2.2227

Valproic acid (VPA) is a widely prescribed antiepileptic drug with various medicinal efficacies. Accumulated evidence implied that prenatal exposure to VPA is highly associated with autism spectrum disorder (ASD). In this study, the zebrafish were exposed to a set of VPA concentrations (0, 5, 10, 20...