Discovery of a novel dual functional phenylpyrazole-styryl hybrid that induces apoptotic and autophagic cell death in bladder cancer cells

• Main Authors: Leong, Sze Wei, Wang, JingJing, Okuda, Kazuhide Shaun, Su, Qi, Zhang, Yanmin, Abas, Faridah, Chia, Suet Lin, Yusoff, Khatijah
• Format: Article
• Language: English
• Published: Elsevier 2023
• Online Access: http://psasir.upm.edu.my/id/eprint/107356/1/107356.pdf; http://psasir.upm.edu.my/id/eprint/107356/; https://www.sciencedirect.com/science/article/pii/S022352342300301X?via%3Dihub

Unpleasant side effects and resistance development remained the Achilles heel of chemotherapy. Since low tumor-selectivity and monotonous effect of chemotherapy are closely related to such bottleneck, targeting tumor-selective multi-functional anticancer agents may be an ideal strategy in the search...