Current insights on dyslipidaemia management for prevention of atherosclerotic cardiovascular disease: a malaysian perspective

Dyslipidaemia is highly prevalent in the Malaysian population and is one of the main risk factors for atherosclerotic cardiovascular disease (ASCVD). Low-density lipoprotein cholesterol (LDL-C) is recognised as the primary target of lipid-lowering therapy to reduce the disease burden of ASCVD. Frami...

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Main Authors: Wan Ahmad, Wan Azman, Rosman, Azhari, Bavanandan, Sunita, Mohamed, Mafauzy, Sk Abdul Kader, Muhamad Ali, Muthusamy, Tamil Selvan, Lam, Kai Huat, Kasim, Sazzli Shahlan, Hoo, Fan Kee, Fegade, Mayuresh, Looi, Zhi Ling, Abdul Rahman, Abdul Rashid
Format: Article
Language:English
Published: Penerbit Universiti Sains Malaysia 2023
Online Access:http://psasir.upm.edu.my/id/eprint/107195/1/Current%20insights%20on%20dyslipidaemia%20management%20for%20prevention%20of%20atherosclerotic%20cardiovascular%20disease.pdf
http://psasir.upm.edu.my/id/eprint/107195/
http://www.mjms.usm.my/MJMS30012023/MJMS30012023_06.pdf
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spelling my.upm.eprints.1071952024-10-17T03:43:52Z http://psasir.upm.edu.my/id/eprint/107195/ Current insights on dyslipidaemia management for prevention of atherosclerotic cardiovascular disease: a malaysian perspective Wan Ahmad, Wan Azman Rosman, Azhari Bavanandan, Sunita Mohamed, Mafauzy Sk Abdul Kader, Muhamad Ali Muthusamy, Tamil Selvan Lam, Kai Huat Kasim, Sazzli Shahlan Hoo, Fan Kee Fegade, Mayuresh Looi, Zhi Ling Abdul Rahman, Abdul Rashid Dyslipidaemia is highly prevalent in the Malaysian population and is one of the main risk factors for atherosclerotic cardiovascular disease (ASCVD). Low-density lipoprotein cholesterol (LDL-C) is recognised as the primary target of lipid-lowering therapy to reduce the disease burden of ASCVD. Framingham General CV Risk Score has been validated in the Malaysian population for CV risk assessment. The Clinical Practice Guidelines (CPG) on the management of dyslipidaemia were last updated in 2017. Since its publication, several newer randomised clinical trials have been conducted with their results published in research articles and compared in meta-analysis. This underscores a need to update the previous guidelines to ensure good quality care and treatment for the patients. This review summarises the benefits of achieving LDL-C levels lower than the currently recommended target of < 1.8mmol/L without any safety concerns. In most high and very high-risk individuals, statins are the first line of therapy for dyslipidaemia management. However, certain high-risk individuals are not able to achieve the LDL-C goal as recommended in the guideline even with high-intensity statin therapy. In such individuals, lower LDL-C levels can be achieved by combining the statins with non-statin agents such as ezetimibe and PCSK9 inhibitors. Emerging non-statin lipid-lowering therapies and challenges in dyslipidaemia management are discussed in this article. The review also summarises the recent updates on local and international guidelines for dyslipidaemia management. Penerbit Universiti Sains Malaysia 2023-02 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/107195/1/Current%20insights%20on%20dyslipidaemia%20management%20for%20prevention%20of%20atherosclerotic%20cardiovascular%20disease.pdf Wan Ahmad, Wan Azman and Rosman, Azhari and Bavanandan, Sunita and Mohamed, Mafauzy and Sk Abdul Kader, Muhamad Ali and Muthusamy, Tamil Selvan and Lam, Kai Huat and Kasim, Sazzli Shahlan and Hoo, Fan Kee and Fegade, Mayuresh and Looi, Zhi Ling and Abdul Rahman, Abdul Rashid (2023) Current insights on dyslipidaemia management for prevention of atherosclerotic cardiovascular disease: a malaysian perspective. Malaysian Journal of Medical Sciences, 30 (1). 67- 81. ISSN 1394-195X,2180-4303 http://www.mjms.usm.my/MJMS30012023/MJMS30012023_06.pdf 10.21315/mjms2023.30.1.6
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Dyslipidaemia is highly prevalent in the Malaysian population and is one of the main risk factors for atherosclerotic cardiovascular disease (ASCVD). Low-density lipoprotein cholesterol (LDL-C) is recognised as the primary target of lipid-lowering therapy to reduce the disease burden of ASCVD. Framingham General CV Risk Score has been validated in the Malaysian population for CV risk assessment. The Clinical Practice Guidelines (CPG) on the management of dyslipidaemia were last updated in 2017. Since its publication, several newer randomised clinical trials have been conducted with their results published in research articles and compared in meta-analysis. This underscores a need to update the previous guidelines to ensure good quality care and treatment for the patients. This review summarises the benefits of achieving LDL-C levels lower than the currently recommended target of < 1.8mmol/L without any safety concerns. In most high and very high-risk individuals, statins are the first line of therapy for dyslipidaemia management. However, certain high-risk individuals are not able to achieve the LDL-C goal as recommended in the guideline even with high-intensity statin therapy. In such individuals, lower LDL-C levels can be achieved by combining the statins with non-statin agents such as ezetimibe and PCSK9 inhibitors. Emerging non-statin lipid-lowering therapies and challenges in dyslipidaemia management are discussed in this article. The review also summarises the recent updates on local and international guidelines for dyslipidaemia management.
format Article
author Wan Ahmad, Wan Azman
Rosman, Azhari
Bavanandan, Sunita
Mohamed, Mafauzy
Sk Abdul Kader, Muhamad Ali
Muthusamy, Tamil Selvan
Lam, Kai Huat
Kasim, Sazzli Shahlan
Hoo, Fan Kee
Fegade, Mayuresh
Looi, Zhi Ling
Abdul Rahman, Abdul Rashid
spellingShingle Wan Ahmad, Wan Azman
Rosman, Azhari
Bavanandan, Sunita
Mohamed, Mafauzy
Sk Abdul Kader, Muhamad Ali
Muthusamy, Tamil Selvan
Lam, Kai Huat
Kasim, Sazzli Shahlan
Hoo, Fan Kee
Fegade, Mayuresh
Looi, Zhi Ling
Abdul Rahman, Abdul Rashid
Current insights on dyslipidaemia management for prevention of atherosclerotic cardiovascular disease: a malaysian perspective
author_facet Wan Ahmad, Wan Azman
Rosman, Azhari
Bavanandan, Sunita
Mohamed, Mafauzy
Sk Abdul Kader, Muhamad Ali
Muthusamy, Tamil Selvan
Lam, Kai Huat
Kasim, Sazzli Shahlan
Hoo, Fan Kee
Fegade, Mayuresh
Looi, Zhi Ling
Abdul Rahman, Abdul Rashid
author_sort Wan Ahmad, Wan Azman
title Current insights on dyslipidaemia management for prevention of atherosclerotic cardiovascular disease: a malaysian perspective
title_short Current insights on dyslipidaemia management for prevention of atherosclerotic cardiovascular disease: a malaysian perspective
title_full Current insights on dyslipidaemia management for prevention of atherosclerotic cardiovascular disease: a malaysian perspective
title_fullStr Current insights on dyslipidaemia management for prevention of atherosclerotic cardiovascular disease: a malaysian perspective
title_full_unstemmed Current insights on dyslipidaemia management for prevention of atherosclerotic cardiovascular disease: a malaysian perspective
title_sort current insights on dyslipidaemia management for prevention of atherosclerotic cardiovascular disease: a malaysian perspective
publisher Penerbit Universiti Sains Malaysia
publishDate 2023
url http://psasir.upm.edu.my/id/eprint/107195/1/Current%20insights%20on%20dyslipidaemia%20management%20for%20prevention%20of%20atherosclerotic%20cardiovascular%20disease.pdf
http://psasir.upm.edu.my/id/eprint/107195/
http://www.mjms.usm.my/MJMS30012023/MJMS30012023_06.pdf
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score 13.209306