Effect of gamma irradiation on the size of cellulose nanocrystals with polyethylene glycol and sodium hydroxide/Gd2O3 nanocomposite as contrast agent in magnetic resonance imaging (MRI)

• Main Authors: Whba, Fathyah, Mohamed, Faizal, Idris, Mohd Idzat, Whba, Rawdah, Mohd Noor, Noramaliza
• Format: Article
• Language: English
• Published: Korean Nuclear Society 2024
• Online Access: http://psasir.upm.edu.my/id/eprint/105845/1/1-s2.0-S1738573323005892-main.pdf; http://psasir.upm.edu.my/id/eprint/105845/; https://www.sciencedirect.com/science/article/pii/S1738573323005892

The attractive properties of gadolinium-based nanoparticles as a positive contrast agent for magnetic resonance imaging (MRI) have piqued the interest of both researchers and clinicians. Nonetheless, due to the biotoxicity of gadolinium (III) ions' free radicals, there is a need to address this issue. Therefore, this research aimed to develop a biocompatible, dispersible, stable, hydrophilic, and less toxic cellulose nanocrystals/gadolinium oxide nanocomposite as contrast agent properties for MRI purposes. This study aimed to synthesize gadolinium oxide nanoparticles coated with cellulose nanocrystals with polyethylene glycol and sodium hydroxide (CNCs-PEG/NaOH)/Gd2O3 using the gamma irradiation method to reduce the particle size. The results showed that using a gamma irradiation dose of 10 kGy, quasi-spherical morphology with a size of approximately 5.5 ± 0.65 nm could be produced. Furthermore, the cytocompatibility of (CNCs-PEG/NaOH)/Gd2O3 nanocomposite synthesized was assessed through MTT assay tests on Hep G2 cells, which demonstrated good cytocompatibility without any cytotoxic effects within a concentration range of (10 μg/mL −150 μg/mL) and had sufficient cellular uptake. Moreover, the T1-weighted MRI of (CNCs-PEG/NaOH)/Gd2O3 nanocomposite revealed promising results as a positive contrast agent. It is envisaged that the gamma irradiation method is promising in synthesizing (CNCs-PEG/NaOH)/Gd2O3 nanocomposite with nanoscale for different applications, especially in the radiotherapy field.