Performance evaluation of Gallium-68 radiopharmaceuticals production using liquid target PETtrace 800 cyclotron

• Main Authors: Ashhar, Zarif, Ahmad Fadzil, Muhammad Fakhrurazi, Md Safee, Zaitulhusna, Aziz, Firdaus, Ibarhim, Ummi Habibah, Nik Afinde, Nik Muhammad Fitri, Mat Ail, Noratikah, Jamal Harizan, Muhammad Ali Hazizi, Halib, Dzulieza, Alek Amran, Arieffuddin, Adawiyah, Rabiatul, Abd Hamid, Mohd Hamdi Noor, Mahamood, Mazurin, Razali, Nor Idayu, Said, Mohamad Aminudin
• Format: Article
• Published: Elsevier 2024
• Online Access: http://psasir.upm.edu.my/id/eprint/105669/; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85181677046&doi=10.1016%2fj.apradiso.2023.111161&partnerID=40&md5=24b6cda6e36934e80f555173c530027f

Due to increased demand, cyclotron has an expanding role in producing Gallium-68 (68Ga) radiopharmaceuticals using solid and liquid targets. Though the liquid target produces lower end-of-bombardment activity compared to the solid target, our study presents the performance of 68Ga radiopharmaceuticals production using the liquid target by evaluating the end-of-bombardment activity and the end-of-purification activity of 68GaGaCl3. We also present the effect of increasing irradiation time, which significantly improves the end-of-synthesis yield. From the result obtained, the end-of-bombardment activity produced was 4.48 GBq, and the 68GaGaCl3 end-of-purification activity produced was 2.51 GBq with below-limit metallic impurities. Increasing the irradiation time showed a significant increase in the end-of-synthesis activity from 1.33 GBq to 1.95 GBq for 68GaGa-PSMA-11 and from 1.13 GBq to 1.74 GBq for 68GaGa-DOTA-TATE. Based on the improvements made, the liquid target production of 68Ga radiopharmaceuticals is feasible and reproducible to accommodate up to 5 patients per production. In addition, this work also discusses the issues encountered, together with the possible corrective and preventative measures. © 2023 Elsevier Ltd