In vitro protective effects of 2,4,6-trihydroxy-3-geranyl acetophenone on junctional protein disruption and the underlying signaling pathways in lipopolysaccharide-induced endothelial hyperpermeability

• Main Author: Chan, Yee Han
• Format: Thesis
• Language: English
• Published: 2022
• Subjects: Pathogenesis of Disease; Endothelial Cells; Lipopolysaccharides
• Online Access: http://psasir.upm.edu.my/id/eprint/103917/1/CHAN%20YEE%20HAN%20-%20IR.pdf; http://psasir.upm.edu.my/id/eprint/103917/

Endothelial hyperpermeability is a prominent hallmark in the pathogenesis of diseases such as sepsis and endotoxemia. Proinflammatory stimuli such as lipopolysaccharide (LPS) could trigger the overproduction of proinflammatory mediators and activate multiple signaling pathways, thereby resulting in...