The role of krüppel-like factor 4 (klf4) gene in breast cancer tissue samples: a systematic review and meta-analysis

Background: Breast cancer is the most common cancer and the primary cause of mortality due to cancer in female around the World. As a result, the aim of this research is to conduct a comprehensive systematic review and meta-analysis to determine the role of Krüppel-like factor 4 (KLF4) as the main g...

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Main Authors: Salari, Nader, Rasoulpoor, Shabnam, Rasoulpoor, Shna, Mansouri, Kamran, Shohaimi, Shamarina, Mohammadi, Masoud
Format: Article
Published: Springer 2022
Online Access:http://psasir.upm.edu.my/id/eprint/103728/
https://link.springer.com/article/10.1007/s40944-022-00605-4
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spelling my.upm.eprints.1037282023-04-14T08:01:47Z http://psasir.upm.edu.my/id/eprint/103728/ The role of krüppel-like factor 4 (klf4) gene in breast cancer tissue samples: a systematic review and meta-analysis Salari, Nader Rasoulpoor, Shabnam Rasoulpoor, Shna Mansouri, Kamran Shohaimi, Shamarina Mohammadi, Masoud Background: Breast cancer is the most common cancer and the primary cause of mortality due to cancer in female around the World. As a result, the aim of this research is to conduct a comprehensive systematic review and meta-analysis to determine the role of Krüppel-like factor 4 (KLF4) as the main gene expression in breast cancer tissue. Methods: The studies used in this systematic review were selected from the articles published from up to February 1, 2020, in national and international databases including SID, WoS, Magiran, PubMed, Scopus, IranDoc, Science Direct, IranMedix as well as Google Scholar. Results: From the systematic review, a meta-analysis was performed on 8 articles which were satisfied the inclusion criteria. The sample including 869 individuals was then selected to perform the meta-analysis. Based on the results derived from this meta-analysis, the total expression of klf4 gene in breast cancer tissue’s samples was 60.1% (95% CI: 45.1–73.4%). The highest and lowest Klf4 gene expression levels in breast cancer tissue samples were obtained 89.7% in Alabama in 2004 (95% CI: 83.7–93.7%) and 32.1% in Japan in 2016 (95% CI: 23.1–42.8%), respectively. The results showed that with increasing sample size and year of publication, klf4 gene expression was reduced in breast cancer tissue samples, which was statistically significant (P < 0.05). Conclusion: Identifying the expression profiles of genes involved in breast cancer using its various pathway inhibitors can address many challenges for researchers and is very important for advancing cancer health and treatment. Springer 2022 Article PeerReviewed Salari, Nader and Rasoulpoor, Shabnam and Rasoulpoor, Shna and Mansouri, Kamran and Shohaimi, Shamarina and Mohammadi, Masoud (2022) The role of krüppel-like factor 4 (klf4) gene in breast cancer tissue samples: a systematic review and meta-analysis. Indian journal of Gynecologic Oncology, 20. art. no. 7. pp. 1-9. ISSN 2363-8397; ESSN: 2363-8400 https://link.springer.com/article/10.1007/s40944-022-00605-4 10.1007/s40944-022-00605-4
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description Background: Breast cancer is the most common cancer and the primary cause of mortality due to cancer in female around the World. As a result, the aim of this research is to conduct a comprehensive systematic review and meta-analysis to determine the role of Krüppel-like factor 4 (KLF4) as the main gene expression in breast cancer tissue. Methods: The studies used in this systematic review were selected from the articles published from up to February 1, 2020, in national and international databases including SID, WoS, Magiran, PubMed, Scopus, IranDoc, Science Direct, IranMedix as well as Google Scholar. Results: From the systematic review, a meta-analysis was performed on 8 articles which were satisfied the inclusion criteria. The sample including 869 individuals was then selected to perform the meta-analysis. Based on the results derived from this meta-analysis, the total expression of klf4 gene in breast cancer tissue’s samples was 60.1% (95% CI: 45.1–73.4%). The highest and lowest Klf4 gene expression levels in breast cancer tissue samples were obtained 89.7% in Alabama in 2004 (95% CI: 83.7–93.7%) and 32.1% in Japan in 2016 (95% CI: 23.1–42.8%), respectively. The results showed that with increasing sample size and year of publication, klf4 gene expression was reduced in breast cancer tissue samples, which was statistically significant (P < 0.05). Conclusion: Identifying the expression profiles of genes involved in breast cancer using its various pathway inhibitors can address many challenges for researchers and is very important for advancing cancer health and treatment.
format Article
author Salari, Nader
Rasoulpoor, Shabnam
Rasoulpoor, Shna
Mansouri, Kamran
Shohaimi, Shamarina
Mohammadi, Masoud
spellingShingle Salari, Nader
Rasoulpoor, Shabnam
Rasoulpoor, Shna
Mansouri, Kamran
Shohaimi, Shamarina
Mohammadi, Masoud
The role of krüppel-like factor 4 (klf4) gene in breast cancer tissue samples: a systematic review and meta-analysis
author_facet Salari, Nader
Rasoulpoor, Shabnam
Rasoulpoor, Shna
Mansouri, Kamran
Shohaimi, Shamarina
Mohammadi, Masoud
author_sort Salari, Nader
title The role of krüppel-like factor 4 (klf4) gene in breast cancer tissue samples: a systematic review and meta-analysis
title_short The role of krüppel-like factor 4 (klf4) gene in breast cancer tissue samples: a systematic review and meta-analysis
title_full The role of krüppel-like factor 4 (klf4) gene in breast cancer tissue samples: a systematic review and meta-analysis
title_fullStr The role of krüppel-like factor 4 (klf4) gene in breast cancer tissue samples: a systematic review and meta-analysis
title_full_unstemmed The role of krüppel-like factor 4 (klf4) gene in breast cancer tissue samples: a systematic review and meta-analysis
title_sort role of krüppel-like factor 4 (klf4) gene in breast cancer tissue samples: a systematic review and meta-analysis
publisher Springer
publishDate 2022
url http://psasir.upm.edu.my/id/eprint/103728/
https://link.springer.com/article/10.1007/s40944-022-00605-4
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