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Clinical and laboratory observation on immunoglobulin replacement therapy switching from an intravenous to a subcutaneous route in a Malaysian X-linked agammaglobulinemia patient

We report a clinical and laboratory observation in a boy with X-linked agammaglobulinemia (XLA) who underwent an immunoglobulin replacement therapy (IRT) via the subcutaneous route (IGSC) seven years after his IRT via intravenous route (IGIV). He was free of invasive infections when on IGIV but not...

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Main Authors: Ali, Adli, Abdul Wahab, Asrul, Abdul Latiff, Amir Hamzah, Ismail, Intan Hakimah, Mohd Zaki, Faizah, Borhanuddin, Boekhren Karyostyko, Mohd Noh, Lokman
Format: Article
Published: Malaysian Medical Association 2022
Online Access:http://psasir.upm.edu.my/id/eprint/100706/
https://www.e-mjm.org/2022/v77n1/index.html
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spelling my.upm.eprints.1007062023-09-15T07:56:45Z http://psasir.upm.edu.my/id/eprint/100706/ Clinical and laboratory observation on immunoglobulin replacement therapy switching from an intravenous to a subcutaneous route in a Malaysian X-linked agammaglobulinemia patient Ali, Adli Abdul Wahab, Asrul Abdul Latiff, Amir Hamzah Ismail, Intan Hakimah Mohd Zaki, Faizah Borhanuddin, Boekhren Karyostyko Mohd Noh, Lokman We report a clinical and laboratory observation in a boy with X-linked agammaglobulinemia (XLA) who underwent an immunoglobulin replacement therapy (IRT) via the subcutaneous route (IGSC) seven years after his IRT via intravenous route (IGIV). He was free of invasive infections when on IGIV but not the troublesome coughs a week before the next infusion. A switch to a subcutaneous route resulted in significant improvement of symptoms with good weight gain. When on 2-weekly IGSC cycle, adjusting dose for weight resulted in an IgG trough level of > 600 mg/dl. Malaysian Medical Association 2022-01 Article PeerReviewed Ali, Adli and Abdul Wahab, Asrul and Abdul Latiff, Amir Hamzah and Ismail, Intan Hakimah and Mohd Zaki, Faizah and Borhanuddin, Boekhren Karyostyko and Mohd Noh, Lokman (2022) Clinical and laboratory observation on immunoglobulin replacement therapy switching from an intravenous to a subcutaneous route in a Malaysian X-linked agammaglobulinemia patient. Medical Journal of Malaysia, 77 (1). 95 - 97. ISSN 0300-5283 https://www.e-mjm.org/2022/v77n1/index.html
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
description We report a clinical and laboratory observation in a boy with X-linked agammaglobulinemia (XLA) who underwent an immunoglobulin replacement therapy (IRT) via the subcutaneous route (IGSC) seven years after his IRT via intravenous route (IGIV). He was free of invasive infections when on IGIV but not the troublesome coughs a week before the next infusion. A switch to a subcutaneous route resulted in significant improvement of symptoms with good weight gain. When on 2-weekly IGSC cycle, adjusting dose for weight resulted in an IgG trough level of > 600 mg/dl.
format Article
author Ali, Adli
Abdul Wahab, Asrul
Abdul Latiff, Amir Hamzah
Ismail, Intan Hakimah
Mohd Zaki, Faizah
Borhanuddin, Boekhren Karyostyko
Mohd Noh, Lokman
spellingShingle Ali, Adli
Abdul Wahab, Asrul
Abdul Latiff, Amir Hamzah
Ismail, Intan Hakimah
Mohd Zaki, Faizah
Borhanuddin, Boekhren Karyostyko
Mohd Noh, Lokman
Clinical and laboratory observation on immunoglobulin replacement therapy switching from an intravenous to a subcutaneous route in a Malaysian X-linked agammaglobulinemia patient
author_facet Ali, Adli
Abdul Wahab, Asrul
Abdul Latiff, Amir Hamzah
Ismail, Intan Hakimah
Mohd Zaki, Faizah
Borhanuddin, Boekhren Karyostyko
Mohd Noh, Lokman
author_sort Ali, Adli
title Clinical and laboratory observation on immunoglobulin replacement therapy switching from an intravenous to a subcutaneous route in a Malaysian X-linked agammaglobulinemia patient
title_short Clinical and laboratory observation on immunoglobulin replacement therapy switching from an intravenous to a subcutaneous route in a Malaysian X-linked agammaglobulinemia patient
title_full Clinical and laboratory observation on immunoglobulin replacement therapy switching from an intravenous to a subcutaneous route in a Malaysian X-linked agammaglobulinemia patient
title_fullStr Clinical and laboratory observation on immunoglobulin replacement therapy switching from an intravenous to a subcutaneous route in a Malaysian X-linked agammaglobulinemia patient
title_full_unstemmed Clinical and laboratory observation on immunoglobulin replacement therapy switching from an intravenous to a subcutaneous route in a Malaysian X-linked agammaglobulinemia patient
title_sort clinical and laboratory observation on immunoglobulin replacement therapy switching from an intravenous to a subcutaneous route in a malaysian x-linked agammaglobulinemia patient
publisher Malaysian Medical Association
publishDate 2022
url http://psasir.upm.edu.my/id/eprint/100706/
https://www.e-mjm.org/2022/v77n1/index.html
_version_ 1781706686160961536
score 13.209306

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