An insight into the molecular characteristics and associated pathology of chicken astroviruses
The chicken astrovirus (CAstV) is a ubiquitous enteric RNA virus that has been associated mainly with conditions, such as the runting-stunting syndrome, severe kidney disease, visceral gout, and white chick syndrome, in broiler-type chickens worldwide. Sequence analysis of the capsid genes’ amino ac...
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my.upm.eprints.1002552024-07-09T02:32:09Z http://psasir.upm.edu.my/id/eprint/100255/ An insight into the molecular characteristics and associated pathology of chicken astroviruses Abdullahi Raji, Abdullahi Omar, Abdul Rahman The chicken astrovirus (CAstV) is a ubiquitous enteric RNA virus that has been associated mainly with conditions, such as the runting-stunting syndrome, severe kidney disease, visceral gout, and white chick syndrome, in broiler-type chickens worldwide. Sequence analysis of the capsid genes’ amino acids of the strains involved in these conditions reveals a genetic relationship and diversity between and within the CAstV genogroups and subgroups based on phylogenetic analysis, genetic distance (p-dist), and pathogenicity. While the two genogroups (A and B) are demarcated phylogenetically, their pairwise amino acid sequence identity is 39% to 42% at a p-dist of 0.59 to 0.62. Group-A consists of three subgroups (Ai, Aii, and Aiii) with an inter- and intra-subgroup amino acid identity of 78% to 82% and 92% to 100%, respectively, and a p-dist of 0.18 to 0.22. On the other hand, the six subgroups (Bi, Bii, Biii, Biv, Bv, and Bvi) in Group-B, with a p-dist of 0.07 to 0.18, have an inter- and intra-subgroup amino acid identity of 82% to 93% and 93% to 100%, respectively. However, these groupings have little to no effect on determining the type of CAstV-associated pathology in chickens. Multidisciplinary Digital Publishing Institute 2022-03-30 Article PeerReviewed Abdullahi Raji, Abdullahi and Omar, Abdul Rahman (2022) An insight into the molecular characteristics and associated pathology of chicken astroviruses. Viruses, 14 (4). art. no. 722. pp. 1-15. ISSN 1999-4915 https://www.mdpi.com/1999-4915/14/4/722 10.3390/v14040722 |
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The chicken astrovirus (CAstV) is a ubiquitous enteric RNA virus that has been associated mainly with conditions, such as the runting-stunting syndrome, severe kidney disease, visceral gout, and white chick syndrome, in broiler-type chickens worldwide. Sequence analysis of the capsid genes’ amino acids of the strains involved in these conditions reveals a genetic relationship and diversity between and within the CAstV genogroups and subgroups based on phylogenetic analysis, genetic distance (p-dist), and pathogenicity. While the two genogroups (A and B) are demarcated phylogenetically, their pairwise amino acid sequence identity is 39% to 42% at a p-dist of 0.59 to 0.62. Group-A consists of three subgroups (Ai, Aii, and Aiii) with an inter- and intra-subgroup amino acid identity of 78% to 82% and 92% to 100%, respectively, and a p-dist of 0.18 to 0.22. On the other hand, the six subgroups (Bi, Bii, Biii, Biv, Bv, and Bvi) in Group-B, with a p-dist of 0.07 to 0.18, have an inter- and intra-subgroup amino acid identity of 82% to 93% and 93% to 100%, respectively. However, these groupings have little to no effect on determining the type of CAstV-associated pathology in chickens. |
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Abdullahi Raji, Abdullahi Omar, Abdul Rahman |
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Abdullahi Raji, Abdullahi Omar, Abdul Rahman An insight into the molecular characteristics and associated pathology of chicken astroviruses |
author_facet |
Abdullahi Raji, Abdullahi Omar, Abdul Rahman |
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Abdullahi Raji, Abdullahi |
title |
An insight into the molecular characteristics and associated pathology of chicken astroviruses |
title_short |
An insight into the molecular characteristics and associated pathology of chicken astroviruses |
title_full |
An insight into the molecular characteristics and associated pathology of chicken astroviruses |
title_fullStr |
An insight into the molecular characteristics and associated pathology of chicken astroviruses |
title_full_unstemmed |
An insight into the molecular characteristics and associated pathology of chicken astroviruses |
title_sort |
insight into the molecular characteristics and associated pathology of chicken astroviruses |
publisher |
Multidisciplinary Digital Publishing Institute |
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2022 |
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http://psasir.upm.edu.my/id/eprint/100255/ https://www.mdpi.com/1999-4915/14/4/722 |
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