Exploring the dynamics of HIV and CD4+ T-cells with non-integer derivatives involving nonsingular and nonlocal kernel

• Main Authors: Shutaywi M., Shah Z., Vrinceanu N., Jan R., Deebani W.
• Other Authors: 57210147083
• Format: Article
• Published: Nature Research 2025
• Subjects: CD4-Positive T-Lymphocytes; Computer Simulation; HIV Infections; Humans; CD4+ T lymphocyte; computer simulation; human; Human immunodeficiency virus infection; immunology; virology

It is important to examine and comprehend how HIV interacts with the immune system in order to manage the infection, enhance patient outcomes, advance medical research, and support global health and socioeconomic stability. In this study, we formulate the dynamics of HIV infection to investigate the intricate interactions between HIV and T-cells. The Atangana-Baleanu and Caputo-Fabrizio derivative frameworks are applied to comprehensively examine the phenomenon of HIV viral transmission. The basic concepts and results of fractional calculus are presented for the analysis of the model. In our work, we focus on the dynamical behavior of HIV and immune system. We introduce numerical schemes to elucidate the solution pathways of the recommended system of HIV. We have shown the influence of various input factors on the solution pathways of the recommended fractional system and highlighted the oscillatory behavior and chaotic nature of the dynamics. Our findings demonstrate the complexity of the system under study by revealing the existence of the chaotic and oscillatory nature in the dynamics of HIV. In order to quantitatively characterize HIV dynamics, a number of simulations are carried out, providing a visual representation of the effects of different input variables. It has been observed that the chaos and the oscillatory behaviour is strongly related to the nonlinearity of the system. The present study provides a basis for further initiatives that try to enhance interventions and policies to lessen the worldwide burden of infection. ? The Author(s) 2024.