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Antibacterial activity and physicochemical characterization of calcium-aluminium-ciprofloxacin-layered double hydroxide

aluminum derivative; calcium aluminium layered double hydroxide; calcium derivative; ciprofloxacin; drug carrier; nanocomposite; unclassified drug; anion exchange; antibacterial activity; Article; chemical structure; contact time; controlled drug release; decarboxylation; drug decomposition; drug de...

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Main Authors: Jadam M.L., Syed Mohamad S.A., Zaki H.M., Jubri Z., Sarijo S.H.
Other Authors: 57193566449
Format: Article
Published: Editions de Sante 2023
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spelling my.uniten.dspace-262822023-05-29T17:08:40Z Antibacterial activity and physicochemical characterization of calcium-aluminium-ciprofloxacin-layered double hydroxide Jadam M.L. Syed Mohamad S.A. Zaki H.M. Jubri Z. Sarijo S.H. 57193566449 57214148746 56263397100 35778292400 8609580900 aluminum derivative; calcium aluminium layered double hydroxide; calcium derivative; ciprofloxacin; drug carrier; nanocomposite; unclassified drug; anion exchange; antibacterial activity; Article; chemical structure; contact time; controlled drug release; decarboxylation; drug decomposition; drug delivery system; drug solubility; elemental analysis; Escherichia coli; evaporation; field emission scanning electron microscopy; Fourier transform infrared spectroscopy; inductively coupled plasma atomic emission spectrometry; ion exchange; Klebsiella pneumoniae; minimum bactericidal concentration; minimum inhibitory concentration; nonhuman; pH; pore size; pore volume; porosity; Staphylococcus aureus; surface area; surface property; transmission electron microscopy; X ray diffraction A fluoroquinolone antibacterial drug, ciprofloxacin (CPX) was successfully intercalated into calcium�aluminium-layered double hydroxide (CAL) with a molar ratio of 3:1 (Ca:Al) by anion-exchange method. The successful intercalation was confirmed by powder X-ray diffraction (PXRD) pattern analysis, Fourier transform infrared spectroscopy (FTIR), elemental analysis (CHNS), and inductively coupled plasma-atomic emission spectrometry (ICP-AES). The material was also characterized by using field emission scanning electron microscope (FESEM), transmission electron microscopy (TEM), and accelerated surface area and porosity (ASAP) analysis. The basal spacing of calcium-aluminium-ciprofloxacin-layered double hydroxide (CAC) synthesized in this study is 16.2 �, which resulted from the expansion of CAL due to the inclusion of CPX in the interlayer space of the CAL carrier with a loading percentage of 75.9% (w/w). The FTIR spectra of CAC show resemblance to the peaks of CAL and CPX, indicating the inclusion of the drug into the CAL interlayers. The release percentages of the drug into phosphate-buffered saline (PBS) at pH 4.8 and 7.4 are 67% and 60%, respectively, and are best described by the pseudo-second order kinetic model. The antimicrobial activity of CPX, CAL, and CAC were investigated against Escherichia coli, Klebsiella pneumoniae, and Staphylococcus aureus. CAL has a prospective application as a new carrier for CPX. � 2020 Elsevier B.V. Final 2023-05-29T09:08:39Z 2023-05-29T09:08:39Z 2021 Article 10.1016/j.jddst.2020.102314 2-s2.0-85099210287 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099210287&doi=10.1016%2fj.jddst.2020.102314&partnerID=40&md5=23def9c64015b228751b517c045e84da https://irepository.uniten.edu.my/handle/123456789/26282 62 102314 Editions de Sante Scopus
institution Universiti Tenaga Nasional
building UNITEN Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Tenaga Nasional
content_source UNITEN Institutional Repository
url_provider http://dspace.uniten.edu.my/
description aluminum derivative; calcium aluminium layered double hydroxide; calcium derivative; ciprofloxacin; drug carrier; nanocomposite; unclassified drug; anion exchange; antibacterial activity; Article; chemical structure; contact time; controlled drug release; decarboxylation; drug decomposition; drug delivery system; drug solubility; elemental analysis; Escherichia coli; evaporation; field emission scanning electron microscopy; Fourier transform infrared spectroscopy; inductively coupled plasma atomic emission spectrometry; ion exchange; Klebsiella pneumoniae; minimum bactericidal concentration; minimum inhibitory concentration; nonhuman; pH; pore size; pore volume; porosity; Staphylococcus aureus; surface area; surface property; transmission electron microscopy; X ray diffraction
author2 57193566449
author_facet 57193566449
Jadam M.L.
Syed Mohamad S.A.
Zaki H.M.
Jubri Z.
Sarijo S.H.
format Article
author Jadam M.L.
Syed Mohamad S.A.
Zaki H.M.
Jubri Z.
Sarijo S.H.
spellingShingle Jadam M.L.
Syed Mohamad S.A.
Zaki H.M.
Jubri Z.
Sarijo S.H.
Antibacterial activity and physicochemical characterization of calcium-aluminium-ciprofloxacin-layered double hydroxide
author_sort Jadam M.L.
title Antibacterial activity and physicochemical characterization of calcium-aluminium-ciprofloxacin-layered double hydroxide
title_short Antibacterial activity and physicochemical characterization of calcium-aluminium-ciprofloxacin-layered double hydroxide
title_full Antibacterial activity and physicochemical characterization of calcium-aluminium-ciprofloxacin-layered double hydroxide
title_fullStr Antibacterial activity and physicochemical characterization of calcium-aluminium-ciprofloxacin-layered double hydroxide
title_full_unstemmed Antibacterial activity and physicochemical characterization of calcium-aluminium-ciprofloxacin-layered double hydroxide
title_sort antibacterial activity and physicochemical characterization of calcium-aluminium-ciprofloxacin-layered double hydroxide
publisher Editions de Sante
publishDate 2023
_version_ 1806423461435801600
score 13.214268

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