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Preparation and physicochemical characterization of a diclofenac sodium-dual layer polyvinyl alcohol patch

Contact angle; Crystallinity; Fourier transform infrared spectroscopy; Freezing; Gelation; Nanofibers; Physicochemical properties; Polyvinyl alcohols; Scanning electron microscopy; Sodium; Tensile strength; Tensile testing; Thawing; X ray diffraction; Electrospinning techniques; Fourier transform in...

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Main Authors: Sa�adon S., Ansari M.N.M., Razak S.I.A., Anand J.S., Nayan N.H.M., Ismail A.E., Khan M.U.A., Haider A.
Other Authors: 57212346603
Format: Article
Published: MDPI AG 2023
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spelling my.uniten.dspace-260652023-05-29T17:06:29Z Preparation and physicochemical characterization of a diclofenac sodium-dual layer polyvinyl alcohol patch Sa�adon S. Ansari M.N.M. Razak S.I.A. Anand J.S. Nayan N.H.M. Ismail A.E. Khan M.U.A. Haider A. 57212346603 55489853600 57201381533 57206656359 57224123892 57200399068 57195462142 55506147800 Contact angle; Crystallinity; Fourier transform infrared spectroscopy; Freezing; Gelation; Nanofibers; Physicochemical properties; Polyvinyl alcohols; Scanning electron microscopy; Sodium; Tensile strength; Tensile testing; Thawing; X ray diffraction; Electrospinning techniques; Fourier transform infrared; Freeze-thaw process; Morphological structures; Physico-chemical and mechanical properties; Physico-chemical characterization; Spectroscopic technique; Transdermal drug delivery; Drug delivery The aim of this study is to prepare a dual layer polyvinyl (PVA) patch using a combination of electrospinning techniques and cryogelation (freeze-thaw process) then subsequently to investigate the effect of freeze-thaw cycles, nanofiber thickness, and diclofenac sodium (DS) loading on the physicochemical and mechanical properties and formulation of dual layer PVA patches composed of electrospun PVA nanofibers and PVA cryogel. After the successful preparation of the dual layer PVA patch, the prepared patch was subjected to investigation to assess the effect of freeze-thaw cycles, nanofiber thickness and percentages of DS loading on the morphology, physiochemical and mechanical properties. Various spectroscopic techniques such as scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared (FTIR), water contact angle, and tensile tests were used to evaluate the physicochemical and mechanical properties of prepared dual layer PVA patches. The morphological structures of the dual layer PVA patch demonstrated the effectiveness of both techniques. The effect of freeze-thaw cycles, nanofiber thickness, and DS percentage loading on the crystallinity of a dual layer PVA patch was investigated using XRD analysis. The presence of a distinct DS peak in the FTIR spectrum indicates the compatibility of DS in a dual layer PVA patch through in-situ loading. All prepared patches were considered highly hydrophilic because the data obtained was less than 90? . The increasing saturation of DS within the PVA matrix increases the tensile strength of prepared patches, however decreased its elasticity. Evidently, the increasing of electrospun PVA nanofibers thickness, freeze-thaw cycles, and the DS saturation has improved the physicochemical and mechanical properties of the DS medicated dual layer PVA patches, making them a promising biomaterial for transdermal drug delivery applications. � 2021 by the authors. Licensee MDPI, Basel, Switzerland. Final 2023-05-29T09:06:29Z 2023-05-29T09:06:29Z 2021 Article 10.3390/polym13152459 2-s2.0-85111780450 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111780450&doi=10.3390%2fpolym13152459&partnerID=40&md5=651b686decd7c7ac0a70cd3d66acf224 https://irepository.uniten.edu.my/handle/123456789/26065 13 15 2459 All Open Access, Gold, Green MDPI AG Scopus
institution Universiti Tenaga Nasional
building UNITEN Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Tenaga Nasional
content_source UNITEN Institutional Repository
url_provider http://dspace.uniten.edu.my/
description Contact angle; Crystallinity; Fourier transform infrared spectroscopy; Freezing; Gelation; Nanofibers; Physicochemical properties; Polyvinyl alcohols; Scanning electron microscopy; Sodium; Tensile strength; Tensile testing; Thawing; X ray diffraction; Electrospinning techniques; Fourier transform infrared; Freeze-thaw process; Morphological structures; Physico-chemical and mechanical properties; Physico-chemical characterization; Spectroscopic technique; Transdermal drug delivery; Drug delivery
author2 57212346603
author_facet 57212346603
Sa�adon S.
Ansari M.N.M.
Razak S.I.A.
Anand J.S.
Nayan N.H.M.
Ismail A.E.
Khan M.U.A.
Haider A.
format Article
author Sa�adon S.
Ansari M.N.M.
Razak S.I.A.
Anand J.S.
Nayan N.H.M.
Ismail A.E.
Khan M.U.A.
Haider A.
spellingShingle Sa�adon S.
Ansari M.N.M.
Razak S.I.A.
Anand J.S.
Nayan N.H.M.
Ismail A.E.
Khan M.U.A.
Haider A.
Preparation and physicochemical characterization of a diclofenac sodium-dual layer polyvinyl alcohol patch
author_sort Sa�adon S.
title Preparation and physicochemical characterization of a diclofenac sodium-dual layer polyvinyl alcohol patch
title_short Preparation and physicochemical characterization of a diclofenac sodium-dual layer polyvinyl alcohol patch
title_full Preparation and physicochemical characterization of a diclofenac sodium-dual layer polyvinyl alcohol patch
title_fullStr Preparation and physicochemical characterization of a diclofenac sodium-dual layer polyvinyl alcohol patch
title_full_unstemmed Preparation and physicochemical characterization of a diclofenac sodium-dual layer polyvinyl alcohol patch
title_sort preparation and physicochemical characterization of a diclofenac sodium-dual layer polyvinyl alcohol patch
publisher MDPI AG
publishDate 2023
_version_ 1806428439964549120
score 13.214268

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