Staff View: Electrospun nanofiber and cryogel of polyvinyl alcohol transdermal patch containing diclofenac sodium: Preparation, characterization and in vitro release studies

Electrospun nanofiber and cryogel of polyvinyl alcohol transdermal patch containing diclofenac sodium: Preparation, characterization and in vitro release studies

cryogel; diclofenac; nanofiber; polymer; polyvinyl alcohol; Article; biocompatibility; chemical interaction; controlled study; drug synthesis; electrospinning; Fourier transform infrared spectroscopy; freeze thawing; gelation; in vitro study; morphology; pharmacological parameters; physical chemistr...

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Main Authors:	Sa�adon S., Ansari M.N.M., Razak S.I.A., Yusof A.H.M., Faudzi A.A.M., Sagadevan S., Nayan N.H.M., Anand J.S., Amin K.A.M.
Other Authors:	57212346603
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Published:	MDPI 2023
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id	my.uniten.dspace-25916
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spelling	my.uniten.dspace-259162023-05-29T17:05:32Z Electrospun nanofiber and cryogel of polyvinyl alcohol transdermal patch containing diclofenac sodium: Preparation, characterization and in vitro release studies Sa�adon S. Ansari M.N.M. Razak S.I.A. Yusof A.H.M. Faudzi A.A.M. Sagadevan S. Nayan N.H.M. Anand J.S. Amin K.A.M. 57212346603 55489853600 57201381533 14059283400 26028861100 57793664300 57224123892 57206656359 57194435411 cryogel; diclofenac; nanofiber; polymer; polyvinyl alcohol; Article; biocompatibility; chemical interaction; controlled study; drug synthesis; electrospinning; Fourier transform infrared spectroscopy; freeze thawing; gelation; in vitro study; morphology; pharmacological parameters; physical chemistry; scanning electron microscopy; sustained release formulation; thickness Transdermal drug delivery systems (TDDS) have drawn more interest from pharmaceutical scientists because they could provide steady blood levels and prevent the first-pass metabolism over a longer period. Polyvinyl alcohol (PVA) has been widely used in this application due to its biocompatibility, non-toxicity, nanofiber and hydrogel-forming ability. Despite those benefits, their morphology would easily be destroyed by continuous water absorption and contribute to burst drug release due to its hydrophilicity. The aim of this study was to prepare the diclofenac sodium (DS)-medicated dual layer PVA patch using a combination of electrospinning and cryogelation (freeze�thaw) methods to improve the physicochemical properties and drug compatibility and investigate the release of the DS-medicated dual layer PVA patch. Morphological observations using scanning electron microscopy (SEM) verified the polymer?polymer interaction between both layers, whereas Fourier transform infrared (FTIR) spectroscopy has demonstrated the compatibility of DS in PVA matrix up to 2% w/v of PVA volume. The DS loads were found amorphously distributed efficaciously in PVA matrix as no visible spectra of DS�PVA interaction were detected. The DS-medicated dual layer PVA patch with a thicker nanofiber layer (3-milliliter running volume), three freeze�thaw cycles and 2% DS loading labeled as 2%DLB 3C show the lowest swelling capacity (18.47%). The in vitro assessment using Franz diffusion cells showed that the 2%DLB 3C indicates a better sustained release of DS, with 53.26% of the DS being released after 12 h. The 2%DLB 3C owned a flux (Jss) of 0.256 mg/cm2 /h and a permeability coefficient (Kp) value of 0.020 cm/h. Thus, the results demonstrate that DS-medicated dual layer PVA patches prepared via a combination of electrospinning and cryogelation are capable of releasing drugs for up to 24 h and can serve as a drug reservoir in the skin, thereby extending the pharmacologic effects of DS. � 2021 by the authors. Licensee MDPI, Basel, Switzerland. Final 2023-05-29T09:05:32Z 2023-05-29T09:05:32Z 2021 Article 10.3390/pharmaceutics13111900 2-s2.0-85119611685 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119611685&doi=10.3390%2fpharmaceutics13111900&partnerID=40&md5=a53c70b566973f90207f72766587aeed https://irepository.uniten.edu.my/handle/123456789/25916 13 11 1900 All Open Access, Gold, Green MDPI Scopus
institution	Universiti Tenaga Nasional
building	UNITEN Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Tenaga Nasional
content_source	UNITEN Institutional Repository
url_provider	http://dspace.uniten.edu.my/
description	cryogel; diclofenac; nanofiber; polymer; polyvinyl alcohol; Article; biocompatibility; chemical interaction; controlled study; drug synthesis; electrospinning; Fourier transform infrared spectroscopy; freeze thawing; gelation; in vitro study; morphology; pharmacological parameters; physical chemistry; scanning electron microscopy; sustained release formulation; thickness
author2	57212346603
author_facet	57212346603 Sa�adon S. Ansari M.N.M. Razak S.I.A. Yusof A.H.M. Faudzi A.A.M. Sagadevan S. Nayan N.H.M. Anand J.S. Amin K.A.M.
format	Article
author	Sa�adon S. Ansari M.N.M. Razak S.I.A. Yusof A.H.M. Faudzi A.A.M. Sagadevan S. Nayan N.H.M. Anand J.S. Amin K.A.M.
spellingShingle	Sa�adon S. Ansari M.N.M. Razak S.I.A. Yusof A.H.M. Faudzi A.A.M. Sagadevan S. Nayan N.H.M. Anand J.S. Amin K.A.M. Electrospun nanofiber and cryogel of polyvinyl alcohol transdermal patch containing diclofenac sodium: Preparation, characterization and in vitro release studies
author_sort	Sa�adon S.
title	Electrospun nanofiber and cryogel of polyvinyl alcohol transdermal patch containing diclofenac sodium: Preparation, characterization and in vitro release studies
title_short	Electrospun nanofiber and cryogel of polyvinyl alcohol transdermal patch containing diclofenac sodium: Preparation, characterization and in vitro release studies
title_full	Electrospun nanofiber and cryogel of polyvinyl alcohol transdermal patch containing diclofenac sodium: Preparation, characterization and in vitro release studies
title_fullStr	Electrospun nanofiber and cryogel of polyvinyl alcohol transdermal patch containing diclofenac sodium: Preparation, characterization and in vitro release studies
title_full_unstemmed	Electrospun nanofiber and cryogel of polyvinyl alcohol transdermal patch containing diclofenac sodium: Preparation, characterization and in vitro release studies
title_sort	electrospun nanofiber and cryogel of polyvinyl alcohol transdermal patch containing diclofenac sodium: preparation, characterization and in vitro release studies
publisher	MDPI
publishDate	2023
_version_	1806426359426187264
score	13.188404

Electrospun nanofiber and cryogel of polyvinyl alcohol transdermal patch containing diclofenac sodium: Preparation, characterization and in vitro release studies

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