Reflexin A, a new indole alkaloid from Rauvolfia reflexa induces apoptosis against colon cancer cells
antineoplastic agent; caspase 3; caspase 7; caspase 8; caspase 9; indole alkaloid; macusine; Rauvolfia reflexa extract; Rauwolfia extract; reflexin A; unclassified drug; vinorine; flavanone derivative; indole alkaloid; reflexin; acute toxicity; antineoplastic activity; apoptosis; Article; bark; cell...
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2023
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my.uniten.dspace-254882023-05-29T16:10:03Z Reflexin A, a new indole alkaloid from Rauvolfia reflexa induces apoptosis against colon cancer cells Fadaeinasab M. Karimian H. Omar H. Taha H. khorasani A. Banisalam B. Aziz Ketuly K. Abdullah Z. 55662460000 55314150600 35171066800 54279619100 37021530300 51061004500 53879355900 24767273800 antineoplastic agent; caspase 3; caspase 7; caspase 8; caspase 9; indole alkaloid; macusine; Rauvolfia reflexa extract; Rauwolfia extract; reflexin A; unclassified drug; vinorine; flavanone derivative; indole alkaloid; reflexin; acute toxicity; antineoplastic activity; apoptosis; Article; bark; cell invasion; cell migration; cell proliferation; colon cancer; controlled study; drug isolation; drug safety; drug structure; enzyme activation; G1 phase cell cycle checkpoint; HCT 116 cell line; human; human cell; IC50; Rauvolfia reflexa; Rauwolfia; apoptosis; chemical structure; colon tumor; Apoptosis; Colonic Neoplasms; Flavanones; Humans; Indole Alkaloids; Molecular Structure; Rauwolfia One new indole alkaloid, reflexin A (1), and two known indoles, macusine B (2) and vinorine (3), were isolated from the bark of Rauvolfia reflexa. Their structures were elucidated by 1D and 2D NMR, UV, IR, and MS spectroscopic analyses. Compound 1 displayed anticancer activity against HCT-116 colon cancer cells with an IC50 value of 30.24 � 0.75 �M. The results implied that the newly isolated 1 induced apoptosis in HCT-116 cells, suggesting its possible role as an anticancer agent. In vivo acute toxicity study was performed on compound 1 to evaluate its safety profile. � 2019, � 2019 Informa UK Limited, trading as Taylor & Francis Group. Final 2023-05-29T08:10:03Z 2023-05-29T08:10:03Z 2020 Article 10.1080/10286020.2019.1588888 2-s2.0-85063860778 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85063860778&doi=10.1080%2f10286020.2019.1588888&partnerID=40&md5=088cfd360c026561003fddb204617b41 https://irepository.uniten.edu.my/handle/123456789/25488 22 5 474 488 Taylor and Francis Ltd. Scopus |
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antineoplastic agent; caspase 3; caspase 7; caspase 8; caspase 9; indole alkaloid; macusine; Rauvolfia reflexa extract; Rauwolfia extract; reflexin A; unclassified drug; vinorine; flavanone derivative; indole alkaloid; reflexin; acute toxicity; antineoplastic activity; apoptosis; Article; bark; cell invasion; cell migration; cell proliferation; colon cancer; controlled study; drug isolation; drug safety; drug structure; enzyme activation; G1 phase cell cycle checkpoint; HCT 116 cell line; human; human cell; IC50; Rauvolfia reflexa; Rauwolfia; apoptosis; chemical structure; colon tumor; Apoptosis; Colonic Neoplasms; Flavanones; Humans; Indole Alkaloids; Molecular Structure; Rauwolfia |
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55662460000 |
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55662460000 Fadaeinasab M. Karimian H. Omar H. Taha H. khorasani A. Banisalam B. Aziz Ketuly K. Abdullah Z. |
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Fadaeinasab M. Karimian H. Omar H. Taha H. khorasani A. Banisalam B. Aziz Ketuly K. Abdullah Z. |
| spellingShingle |
Fadaeinasab M. Karimian H. Omar H. Taha H. khorasani A. Banisalam B. Aziz Ketuly K. Abdullah Z. Reflexin A, a new indole alkaloid from Rauvolfia reflexa induces apoptosis against colon cancer cells |
| author_sort |
Fadaeinasab M. |
| title |
Reflexin A, a new indole alkaloid from Rauvolfia reflexa induces apoptosis against colon cancer cells |
| title_short |
Reflexin A, a new indole alkaloid from Rauvolfia reflexa induces apoptosis against colon cancer cells |
| title_full |
Reflexin A, a new indole alkaloid from Rauvolfia reflexa induces apoptosis against colon cancer cells |
| title_fullStr |
Reflexin A, a new indole alkaloid from Rauvolfia reflexa induces apoptosis against colon cancer cells |
| title_full_unstemmed |
Reflexin A, a new indole alkaloid from Rauvolfia reflexa induces apoptosis against colon cancer cells |
| title_sort |
reflexin a, a new indole alkaloid from rauvolfia reflexa induces apoptosis against colon cancer cells |
| publisher |
Taylor and Francis Ltd. |
| publishDate |
2023 |
| _version_ |
1806423962143424512 |
| score |
13.214268 |