Toxicity evaluation of graphene and poly(Lactic-acid) using a nematode model
Biology; Cell proliferation; Feeding; Lactic acid; Toxicity; Biodegradable thermoplastics; Caenorhabditis elegans; Feeding activities; Mechanical and thermal properties; Poly lactic acid; Reproductive rates; Unlimited potentials; Untreated control; Graphene
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Trans Tech Publications Ltd
2023
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my.uniten.dspace-250032023-05-29T15:30:12Z Toxicity evaluation of graphene and poly(Lactic-acid) using a nematode model Kong C. Aziz A.I. Kakarla A.B. Kong I. Kong W. 55851490800 57209460263 57209451543 56434024800 26531266200 Biology; Cell proliferation; Feeding; Lactic acid; Toxicity; Biodegradable thermoplastics; Caenorhabditis elegans; Feeding activities; Mechanical and thermal properties; Poly lactic acid; Reproductive rates; Unlimited potentials; Untreated control; Graphene Graphene has gained tremendous attention due to its unlimited potential in various applications while poly(lactic acid) (PLA) is a biodegradable thermoplastic polyester produced from fermenting corn starch. The incorporation of graphene into PLA has been proven to exhibit excellent mechanical and thermal properties. However, there are not many reports on the potential toxic effect of these materials towards living organisms. In this study, we investigated the possible toxicity of graphene and PLA-graphene in a live animal model, the nematode Caenorhabdits elegans (C. elegans). Alive adult worms were exposed directly to graphene and PLA-graphene across a range of concentrations from 50 �g/mL to 1000 �g/mL. After certain hours of exposure, the pharyngeal pumping rate (indicative of the C. elegans feeding activity), reproductive rate and lifespan of the worms were determined and compared to the untreated worm population. At all concentrations tested, both graphene and PLA-graphene do not affect the feeding rate of the nematode. Additionally, there was no significant difference between the lifespan of worms exposed to graphene and PLA-graphene as compared to the untreated control population (p>0.05). We examined the effect of graphene on nematode�s ability to reproduce and no reduction in progenies was detected (p>0.05). Taken together, our findings suggest that graphene and PLA-graphene do not possess a negative effect on the feeding activity, reproduction and overall lifespan of the host, indicating that these materials are safe to living organism at concentration up to 1000 �g/mL. � 2019 Trans Tech Publications Ltd, Switzerland. Final 2023-05-29T07:30:11Z 2023-05-29T07:30:11Z 2019 Conference Paper 10.4028/www.scientific.net/SSP.290.101 2-s2.0-85067820531 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85067820531&doi=10.4028%2fwww.scientific.net%2fSSP.290.101&partnerID=40&md5=d4972ed4d4ebe85677aa97d6418f566c https://irepository.uniten.edu.my/handle/123456789/25003 290 SSP 101 106 Trans Tech Publications Ltd Scopus |
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Malaysia |
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Universiti Tenaga Nasional |
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| description |
Biology; Cell proliferation; Feeding; Lactic acid; Toxicity; Biodegradable thermoplastics; Caenorhabditis elegans; Feeding activities; Mechanical and thermal properties; Poly lactic acid; Reproductive rates; Unlimited potentials; Untreated control; Graphene |
| author2 |
55851490800 |
| author_facet |
55851490800 Kong C. Aziz A.I. Kakarla A.B. Kong I. Kong W. |
| format |
Conference Paper |
| author |
Kong C. Aziz A.I. Kakarla A.B. Kong I. Kong W. |
| spellingShingle |
Kong C. Aziz A.I. Kakarla A.B. Kong I. Kong W. Toxicity evaluation of graphene and poly(Lactic-acid) using a nematode model |
| author_sort |
Kong C. |
| title |
Toxicity evaluation of graphene and poly(Lactic-acid) using a nematode model |
| title_short |
Toxicity evaluation of graphene and poly(Lactic-acid) using a nematode model |
| title_full |
Toxicity evaluation of graphene and poly(Lactic-acid) using a nematode model |
| title_fullStr |
Toxicity evaluation of graphene and poly(Lactic-acid) using a nematode model |
| title_full_unstemmed |
Toxicity evaluation of graphene and poly(Lactic-acid) using a nematode model |
| title_sort |
toxicity evaluation of graphene and poly(lactic-acid) using a nematode model |
| publisher |
Trans Tech Publications Ltd |
| publishDate |
2023 |
| _version_ |
1806426690110357504 |
| score |
13.211869 |