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Performance of Stochastic Targeted Blood Glucose Control Protocol by virtual trials in the Malaysian intensive care unit

Blood; Glucose; Insulin; Intensive care units; Patient treatment; Stochastic control systems; Stochastic models; Blood glucose controls; Blood glucose level; Blood glucose management; Critically-ill patients; Graphical comparison; Hyperglycaemia; Insulin sensitivity; Scale method; Stochastic systems...

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Main Authors:	Jamaludin U.K., M. Suhaimi F., Abdul Razak N.N., Md Ralib A., Mat Nor M.B., Pretty C.G., Humaidi L.
Other Authors:	55330889600
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Published:	Elsevier Ireland Ltd 2023
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spelling	my.uniten.dspace-237432023-05-29T14:51:26Z Performance of Stochastic Targeted Blood Glucose Control Protocol by virtual trials in the Malaysian intensive care unit Jamaludin U.K. M. Suhaimi F. Abdul Razak N.N. Md Ralib A. Mat Nor M.B. Pretty C.G. Humaidi L. 55330889600 36247893200 37059587300 37031770900 57226799207 6508290605 57202156574 Blood; Glucose; Insulin; Intensive care units; Patient treatment; Stochastic control systems; Stochastic models; Blood glucose controls; Blood glucose level; Blood glucose management; Critically-ill patients; Graphical comparison; Hyperglycaemia; Insulin sensitivity; Scale method; Stochastic systems; glucose; insulin; adult; aged; Article; blood glucose monitoring; comorbidity; controlled study; diabetes mellitus; diabetic patient; female; glucose blood level; human; hyperglycemia; insulin blood level; insulin infusion; insulin release; insulin sensitivity; intensive care unit; major clinical study; Malaysia; male; retrospective study; stochastic model; blood; computer simulation; critical illness; diabetes mellitus; diabetic complication; glucose blood level; hyperglycemia; intensive care; Markov chain; middle aged; non insulin dependent diabetes mellitus; reproducibility; Adult; Aged; Blood Glucose; Computer Simulation; Critical Care; Critical Illness; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Type 2; Female; Humans; Hyperglycemia; Intensive Care Units; Malaysia; Male; Middle Aged; Reproducibility of Results; Retrospective Studies; Stochastic Processes Background and objective: Blood glucose variability is common in healthcare and it is not related or influenced by diabetes mellitus. To minimise the risk of high blood glucose in critically ill patients, Stochastic Targeted Blood Glucose Control Protocol is used in intensive care unit at hospitals worldwide. Thus, this study focuses on the performance of stochastic modelling protocol in comparison to the current blood glucose management protocols in the Malaysian intensive care unit. Also, this study is to assess the effectiveness of Stochastic Targeted Blood Glucose Control Protocol when it is applied to a cohort of diabetic patients. Methods: Retrospective data from 210 patients were obtained from a general hospital in Malaysia from May 2014 until June 2015, where 123 patients were having comorbid diabetes mellitus. The comparison of blood glucose control protocol performance between both protocol simulations was conducted through blood glucose fitted with physiological modelling on top of virtual trial simulations, mean calculation of simulation error and several graphical comparisons using stochastic modelling. Results: Stochastic Targeted Blood Glucose Control Protocol reduces hyperglycaemia by 16% in diabetic and 9% in nondiabetic cohorts. The protocol helps to control blood glucose level in the targeted range of 4.0�10.0 mmol/L for 71.8% in diabetic and 82.7% in nondiabetic cohorts, besides minimising the treatment hour up to 71 h for 123 diabetic patients and 39 h for 87 nondiabetic patients. Conclusion: It is concluded that Stochastic Targeted Blood Glucose Control Protocol is good in reducing hyperglycaemia as compared to the current blood glucose management protocol in the Malaysian intensive care unit. Hence, the current Malaysian intensive care unit protocols need to be modified to enhance their performance, especially in the integration of insulin and nutrition intervention in decreasing the hyperglycaemia incidences. Improvement in Stochastic Targeted Blood Glucose Control Protocol in terms of uen model is also a must to adapt with the diabetic cohort. � 2018 Elsevier B.V. Final 2023-05-29T06:51:26Z 2023-05-29T06:51:26Z 2018 Article 10.1016/j.cmpb.2018.03.001 2-s2.0-85047296270 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85047296270&doi=10.1016%2fj.cmpb.2018.03.001&partnerID=40&md5=60eafac5dd700b1c55dd40747b34d3c5 https://irepository.uniten.edu.my/handle/123456789/23743 162 149 155 Elsevier Ireland Ltd Scopus
institution	Universiti Tenaga Nasional
building	UNITEN Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Tenaga Nasional
content_source	UNITEN Institutional Repository
url_provider	http://dspace.uniten.edu.my/
description	Blood; Glucose; Insulin; Intensive care units; Patient treatment; Stochastic control systems; Stochastic models; Blood glucose controls; Blood glucose level; Blood glucose management; Critically-ill patients; Graphical comparison; Hyperglycaemia; Insulin sensitivity; Scale method; Stochastic systems; glucose; insulin; adult; aged; Article; blood glucose monitoring; comorbidity; controlled study; diabetes mellitus; diabetic patient; female; glucose blood level; human; hyperglycemia; insulin blood level; insulin infusion; insulin release; insulin sensitivity; intensive care unit; major clinical study; Malaysia; male; retrospective study; stochastic model; blood; computer simulation; critical illness; diabetes mellitus; diabetic complication; glucose blood level; hyperglycemia; intensive care; Markov chain; middle aged; non insulin dependent diabetes mellitus; reproducibility; Adult; Aged; Blood Glucose; Computer Simulation; Critical Care; Critical Illness; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Type 2; Female; Humans; Hyperglycemia; Intensive Care Units; Malaysia; Male; Middle Aged; Reproducibility of Results; Retrospective Studies; Stochastic Processes
author2	55330889600
author_facet	55330889600 Jamaludin U.K. M. Suhaimi F. Abdul Razak N.N. Md Ralib A. Mat Nor M.B. Pretty C.G. Humaidi L.
format	Article
author	Jamaludin U.K. M. Suhaimi F. Abdul Razak N.N. Md Ralib A. Mat Nor M.B. Pretty C.G. Humaidi L.
spellingShingle	Jamaludin U.K. M. Suhaimi F. Abdul Razak N.N. Md Ralib A. Mat Nor M.B. Pretty C.G. Humaidi L. Performance of Stochastic Targeted Blood Glucose Control Protocol by virtual trials in the Malaysian intensive care unit
author_sort	Jamaludin U.K.
title	Performance of Stochastic Targeted Blood Glucose Control Protocol by virtual trials in the Malaysian intensive care unit
title_short	Performance of Stochastic Targeted Blood Glucose Control Protocol by virtual trials in the Malaysian intensive care unit
title_full	Performance of Stochastic Targeted Blood Glucose Control Protocol by virtual trials in the Malaysian intensive care unit
title_fullStr	Performance of Stochastic Targeted Blood Glucose Control Protocol by virtual trials in the Malaysian intensive care unit
title_full_unstemmed	Performance of Stochastic Targeted Blood Glucose Control Protocol by virtual trials in the Malaysian intensive care unit
title_sort	performance of stochastic targeted blood glucose control protocol by virtual trials in the malaysian intensive care unit
publisher	Elsevier Ireland Ltd
publishDate	2023
_version_	1806426710779887616
score	13.214268

Performance of Stochastic Targeted Blood Glucose Control Protocol by virtual trials in the Malaysian intensive care unit

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