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Cytotoxic and Antioxidant Compounds from the Stem Bark of Goniothalamus tapisoides Mat Salleh

Eleven compounds: goniomicin A (1), goniomicin B (2), goniomicin C (3), goniomicin D (4), tapisoidin (5), goniothalamin (6), 9 deoxygoniopypyrone (7), pterodondiol (8), liriodenine (9), benzamide (10) and cinnamic acid (11), were isolated from the stem bark of Goniothalamus tapisoides. All compounds...

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Main Authors: Rosalind Pei Theng, Kim, Vicky, Bihud, Khalit, Mohamad, Kok Hoong, Leong, Jamaludin, Mohamad, Fasihuddin Badruddin, Ahmad, Hazrina, Hazni, Noraini, Kasim, Siti Nadiah, Abdul Halim, Khalijah, Awang
Format: Article
Language:English
Published: Molecules 2012
Subjects:
AC Collections. Series. Collected works
Online Access:http://ir.unimas.my/id/eprint/97/1/Rosalind.pdf
http://ir.unimas.my/id/eprint/97/
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spelling my.unimas.ir.972023-03-29T03:26:59Z http://ir.unimas.my/id/eprint/97/ Cytotoxic and Antioxidant Compounds from the Stem Bark of Goniothalamus tapisoides Mat Salleh Rosalind Pei Theng, Kim Vicky, Bihud Khalit, Mohamad Kok Hoong, Leong Jamaludin, Mohamad Fasihuddin Badruddin, Ahmad Hazrina, Hazni Noraini, Kasim Siti Nadiah, Abdul Halim Khalijah, Awang AC Collections. Series. Collected works Eleven compounds: goniomicin A (1), goniomicin B (2), goniomicin C (3), goniomicin D (4), tapisoidin (5), goniothalamin (6), 9 deoxygoniopypyrone (7), pterodondiol (8), liriodenine (9), benzamide (10) and cinnamic acid (11), were isolated from the stem bark of Goniothalamus tapisoides. All compounds were identified by spectroscopic analysis and, for known compounds, by comparison with published data. Goniothalamin (6) exhibited mild cytotoxic activity towards a colon cancer cell line (HT-29), with an IC50 value of 64.17 ± 5.60 µM. Goniomicin B (2) give the highest antioxidant activity in the DPPH assay among all compounds tested, with an IC50 of 0.207 µM. Molecules 2012-12-21 Article PeerReviewed text en http://ir.unimas.my/id/eprint/97/1/Rosalind.pdf Rosalind Pei Theng, Kim and Vicky, Bihud and Khalit, Mohamad and Kok Hoong, Leong and Jamaludin, Mohamad and Fasihuddin Badruddin, Ahmad and Hazrina, Hazni and Noraini, Kasim and Siti Nadiah, Abdul Halim and Khalijah, Awang (2012) Cytotoxic and Antioxidant Compounds from the Stem Bark of Goniothalamus tapisoides Mat Salleh. Molecules. pp. 128-139. ISSN 1420-3049 doi:10.3390/molecules18010128
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
language English
topic AC Collections. Series. Collected works
spellingShingle AC Collections. Series. Collected works
Rosalind Pei Theng, Kim
Vicky, Bihud
Khalit, Mohamad
Kok Hoong, Leong
Jamaludin, Mohamad
Fasihuddin Badruddin, Ahmad
Hazrina, Hazni
Noraini, Kasim
Siti Nadiah, Abdul Halim
Khalijah, Awang
Cytotoxic and Antioxidant Compounds from the Stem Bark of Goniothalamus tapisoides Mat Salleh
description Eleven compounds: goniomicin A (1), goniomicin B (2), goniomicin C (3), goniomicin D (4), tapisoidin (5), goniothalamin (6), 9 deoxygoniopypyrone (7), pterodondiol (8), liriodenine (9), benzamide (10) and cinnamic acid (11), were isolated from the stem bark of Goniothalamus tapisoides. All compounds were identified by spectroscopic analysis and, for known compounds, by comparison with published data. Goniothalamin (6) exhibited mild cytotoxic activity towards a colon cancer cell line (HT-29), with an IC50 value of 64.17 ± 5.60 µM. Goniomicin B (2) give the highest antioxidant activity in the DPPH assay among all compounds tested, with an IC50 of 0.207 µM.
format Article
author Rosalind Pei Theng, Kim
Vicky, Bihud
Khalit, Mohamad
Kok Hoong, Leong
Jamaludin, Mohamad
Fasihuddin Badruddin, Ahmad
Hazrina, Hazni
Noraini, Kasim
Siti Nadiah, Abdul Halim
Khalijah, Awang
author_facet Rosalind Pei Theng, Kim
Vicky, Bihud
Khalit, Mohamad
Kok Hoong, Leong
Jamaludin, Mohamad
Fasihuddin Badruddin, Ahmad
Hazrina, Hazni
Noraini, Kasim
Siti Nadiah, Abdul Halim
Khalijah, Awang
author_sort Rosalind Pei Theng, Kim
title Cytotoxic and Antioxidant Compounds from the Stem Bark of Goniothalamus tapisoides Mat Salleh
title_short Cytotoxic and Antioxidant Compounds from the Stem Bark of Goniothalamus tapisoides Mat Salleh
title_full Cytotoxic and Antioxidant Compounds from the Stem Bark of Goniothalamus tapisoides Mat Salleh
title_fullStr Cytotoxic and Antioxidant Compounds from the Stem Bark of Goniothalamus tapisoides Mat Salleh
title_full_unstemmed Cytotoxic and Antioxidant Compounds from the Stem Bark of Goniothalamus tapisoides Mat Salleh
title_sort cytotoxic and antioxidant compounds from the stem bark of goniothalamus tapisoides mat salleh
publisher Molecules
publishDate 2012
url http://ir.unimas.my/id/eprint/97/1/Rosalind.pdf
http://ir.unimas.my/id/eprint/97/
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score 13.18916

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