Pathophysiologic and prognostic role of cytokines in dengue hemorrhagic fever.

• Main Authors: Bethell, Delia B., Flobbe, Karin, Phuong, Cao Xuan Thanh, Day, Nicholas P.J., Phuong, Pham Tung, Buurman, Wim A., Cardosa, Mary Jane, White, Nicholas J., Kwiatkowski, Dominic
• Format: Article
• Language: English
• Published: The University of Chicago 1998
• Subjects: Q Science (General); QR355 Virology; R Medicine (General)
• Online Access: http://ir.unimas.my/id/eprint/7035/1/Pathophysiologic.pdf; http://ir.unimas.my/id/eprint/7035/; http://jid.oxfordjournals.org/content/177/3/778.abstract

Dengue shock syndrome is a severe complication of dengue hemorrhagic fever (DHF), characterized by a massive increase in vascular permeability. Plasma cytokine concentrations were prospectively studied in 443 Vietnamese children with DHF, of whom 6 died. Shock was present in 188 children on admissio...