Recruitment of neutrophils in glomeruli in early mouse sepsis is associated with E-selectin expression and activation of endothelial NF-κB and MAPK pathways

• Main Authors: Zhendong, Wang, Dayang Erna Zulaikha, Awang Hamsin, Peter J., Zwiers, Martha L., Hernandez Garcia, Matthijs, Luxen, Matijs van, Meurs, Jan A.A.M, Kamps, Jill, Moser, Grietje, Molema
• Format: Article
• Language: English
• Published: Oxford Academic 2024
• Subjects: RM Therapeutics. Pharmacology
• Online Access: http://ir.unimas.my/id/eprint/45402/1/7702523_searchresult%3D1; http://ir.unimas.my/id/eprint/45402/; https://academic.oup.com/jleukbio/advance-article/doi/10.1093/jleuko/qiae146/7702523?searchresult=1; https://doi.org/10.1093/jleuko/qiae146

Sepsis is a dysregulated systemic inflammatory response to an infection, which can lead to 18 multiple organ dysfunction syndrome that includes the kidney. Leukocyte recruitment is an 19 important process of the host immune defense in response to sepsis. Endothelial cells (EC) 20 actively regulate...