Red palm olein-enriched biscuit supplementation lowers Ascaris lumbricoides reinfection at 6-month after anthelmintic treatment among schoolchildren with vitamin A deficiency (VAD)
Notwithstanding the global efforts made to control intestinal parasitic infections, soil-transmitted helminth (STH) infections are still one of the most prevalent infections globally, especially in developing countries. A double-blinded, randomized controlled trial was conducted on 343 primary schoo...
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2023
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my.unimas.ir.445512024-04-05T00:57:59Z http://ir.unimas.my/id/eprint/44551/ Red palm olein-enriched biscuit supplementation lowers Ascaris lumbricoides reinfection at 6-month after anthelmintic treatment among schoolchildren with vitamin A deficiency (VAD) Tan, Pei Yee Radhika, Loganathan Teng, Kim-Tiu Lee, Soo Ching Syahirah Nadiah, Mohd Johari Kanga Rani, Selvaduray Romano, Ngui Lim, Yvonne Ai-Lian R Medicine (General) Notwithstanding the global efforts made to control intestinal parasitic infections, soil-transmitted helminth (STH) infections are still one of the most prevalent infections globally, especially in developing countries. A double-blinded, randomized controlled trial was conducted on 343 primary schoolchildren (8-12 years old) with vitamin A deficiency (VAD) in rural areas of Malaysia to investigate the effects of red palm olein (RPO)-enriched biscuits on STH reinfection rates and infection intensities. The effects of the RPO-enriched biscuits (experimental group, n = 153) and palm olein (PO)-enriched biscuits (control group, n = 190), were assessed at 3- and 6-month after the administration of complete triple-dose albendazole (one dose of 400 mg for three consecutive days). The overall STH infection rate at baseline was recorded at 65.6%. At 6-month, a significantly lower reinfection rate of A. lumbricoides was observed in the experimental group (35.3%) compared to the control group (60.0%) (P0.05). These findings suggest the potential beneficial effects of RPO-enriched biscuit supplementation on the reinfection of A. lumbricoides, which could be attributed to its high carotenoids content by enhancing host immune response and mucosal epithelium integrity. However, further studies are warranted to confirm whether RPO supplementation could result in similar parasite-specific beneficial effects in other community settings, as well as to explore the underlying mechanisms. Elsevier B.V. 2023 Article PeerReviewed text en http://ir.unimas.my/id/eprint/44551/2/Red%20palm.pdf Tan, Pei Yee and Radhika, Loganathan and Teng, Kim-Tiu and Lee, Soo Ching and Syahirah Nadiah, Mohd Johari and Kanga Rani, Selvaduray and Romano, Ngui and Lim, Yvonne Ai-Lian (2023) Red palm olein-enriched biscuit supplementation lowers Ascaris lumbricoides reinfection at 6-month after anthelmintic treatment among schoolchildren with vitamin A deficiency (VAD). Acta Tropica, 240. pp. 1-8. ISSN 1873-6254 https://www.sciencedirect.com/science/article/abs/pii/S0001706X23000475?via%3Dihub doi:10.1016/j.actatropica.2023.106860 |
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R Medicine (General) Tan, Pei Yee Radhika, Loganathan Teng, Kim-Tiu Lee, Soo Ching Syahirah Nadiah, Mohd Johari Kanga Rani, Selvaduray Romano, Ngui Lim, Yvonne Ai-Lian Red palm olein-enriched biscuit supplementation lowers Ascaris lumbricoides reinfection at 6-month after anthelmintic treatment among schoolchildren with vitamin A deficiency (VAD) |
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Notwithstanding the global efforts made to control intestinal parasitic infections, soil-transmitted helminth (STH) infections are still one of the most prevalent infections globally, especially in developing countries. A double-blinded, randomized controlled trial was conducted on 343 primary schoolchildren (8-12 years old) with vitamin A deficiency (VAD) in rural areas of Malaysia to investigate the effects of red palm olein (RPO)-enriched biscuits on STH reinfection rates and infection intensities. The effects of the RPO-enriched biscuits (experimental group, n = 153) and palm olein (PO)-enriched biscuits (control group, n = 190), were assessed at 3- and 6-month after the administration of complete triple-dose albendazole (one dose of 400 mg for three consecutive days). The overall STH infection rate at baseline was recorded at 65.6%. At 6-month, a significantly lower reinfection rate of A. lumbricoides was observed in the experimental group (35.3%) compared to the control group (60.0%) (P0.05). These findings suggest the potential beneficial effects of RPO-enriched biscuit supplementation on the reinfection of A. lumbricoides, which could be attributed to its high carotenoids content by enhancing host immune response and mucosal epithelium integrity. However, further studies are warranted to confirm whether RPO supplementation could result in similar parasite-specific beneficial effects in other community settings, as well as to explore the underlying mechanisms. |
format |
Article |
author |
Tan, Pei Yee Radhika, Loganathan Teng, Kim-Tiu Lee, Soo Ching Syahirah Nadiah, Mohd Johari Kanga Rani, Selvaduray Romano, Ngui Lim, Yvonne Ai-Lian |
author_facet |
Tan, Pei Yee Radhika, Loganathan Teng, Kim-Tiu Lee, Soo Ching Syahirah Nadiah, Mohd Johari Kanga Rani, Selvaduray Romano, Ngui Lim, Yvonne Ai-Lian |
author_sort |
Tan, Pei Yee |
title |
Red palm olein-enriched biscuit supplementation lowers Ascaris lumbricoides reinfection at 6-month after anthelmintic treatment among schoolchildren with vitamin A deficiency (VAD) |
title_short |
Red palm olein-enriched biscuit supplementation lowers Ascaris lumbricoides reinfection at 6-month after anthelmintic treatment among schoolchildren with vitamin A deficiency (VAD) |
title_full |
Red palm olein-enriched biscuit supplementation lowers Ascaris lumbricoides reinfection at 6-month after anthelmintic treatment among schoolchildren with vitamin A deficiency (VAD) |
title_fullStr |
Red palm olein-enriched biscuit supplementation lowers Ascaris lumbricoides reinfection at 6-month after anthelmintic treatment among schoolchildren with vitamin A deficiency (VAD) |
title_full_unstemmed |
Red palm olein-enriched biscuit supplementation lowers Ascaris lumbricoides reinfection at 6-month after anthelmintic treatment among schoolchildren with vitamin A deficiency (VAD) |
title_sort |
red palm olein-enriched biscuit supplementation lowers ascaris lumbricoides reinfection at 6-month after anthelmintic treatment among schoolchildren with vitamin a deficiency (vad) |
publisher |
Elsevier B.V. |
publishDate |
2023 |
url |
http://ir.unimas.my/id/eprint/44551/2/Red%20palm.pdf http://ir.unimas.my/id/eprint/44551/ https://www.sciencedirect.com/science/article/abs/pii/S0001706X23000475?via%3Dihub |
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1797543488786530304 |
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13.160551 |