The unrestricted global efort to complete the COOL trial

• Main Authors: Andrew, W. Kirkpatrick, Federico, Coccolini, Matti, Tolonen, Samuel, Minor, Fausto, Catena, Emanuel, Gois Jr., Christopher, J. Doig, Michael, D. Hill, Luca, Ansaloni, Massimo, Chiarugi, Dario, Tartaglia, Orestis, loannidis, Michael, Sugrue, Elif, Colak, S. Morad, Hameed, Hanna, Lampela, Vanni, Agnoletti, Jessica, L. McKee, Naisan, Garraway, Aini Fariza, Ibrahim
• Format: Article
• Language: English
• Published: BioMed Central Ltd. 2023
• Subjects: R Medicine (General)
• Online Access: http://ir.unimas.my/id/eprint/44037/1/The%20unrestricted.pdf; http://ir.unimas.my/id/eprint/44037/; https://wjes.biomedcentral.com/articles/10.1186/s13017-023-00500-z; https://doi.org/10.1186/s13017-023-00500-z

Severe complicated intra-abdominal sepsis (SCIAS) has an increasing incidence with mortality rates over 80% in some settings. Mortality typically results from disruption of the gastrointestinal tract, progressive and self-perpetuating bio-mediator generation, systemic inflammation, and multiple orga...