Unlocking the Antibacterial Potential of Xanthone from Calophyllum Species : Inhibition of Nucleic Acid Synthesis
Plants are valuable resources for the development of novel pharmaceutical products. The increasing threat to global health caused by antibiotic resistance remains a serious concern,driven a need to discover and evaluate novel anti-bacterial agents. Calophyllum species are known for having excellent...
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2023
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my.unimas.ir.436922023-12-14T03:33:23Z http://ir.unimas.my/id/eprint/43692/ Unlocking the Antibacterial Potential of Xanthone from Calophyllum Species : Inhibition of Nucleic Acid Synthesis Dayang Nurul Anisa, Abang Heilman Audrey Yong, Chee Hui Vivien Jong, Yi Mian Fasihuddin Badruddin, Ahmad Lim, Pei Cee Johnson, Stanslas Nor Hisam, Zamakshshari Q Science (General) QD Chemistry R Medicine (General) Plants are valuable resources for the development of novel pharmaceutical products. The increasing threat to global health caused by antibiotic resistance remains a serious concern,driven a need to discover and evaluate novel anti-bacterial agents. Calophyllum species are known for having excellent biological activity due to its secondary metabolites, such as xanthone. Numerous xanthones have been found to possess anti-bacterial properties that are effective against plant pathogens,hence can be applied to fight human pathogens. Topoisomerase enzymes (DNA gyrase and topoisomerase IV) are DNA metabolism enzymes that possess distinct roles as unlinking enzymes during DNA replication. Nucleic acid synthesis inhibition reduces bacteria proliferation through the inhibition of topoisomerase enzymes that are essential for bacterial growth. The xanthone isolated from Calophyllum and its anti-bacterial were discussed in this review. Besides, molecular docking simulations were applied to explore the potential binding mode of xanthones to DNA metabolism enzymes. The docking study displayed that biscaloxanthone is a good topoisomerase enzymes inhibitor compared to their cocystalize ligand, novobiocin and BDBM50198240. The complied information and molecular docking simulations suggested that xanthone isolated possesses potential anti-bacterial agents inhibiting nucleic acid synthesis. Besides, it suggested that the anti-microbial activity of xanthone contributes from the topoisomerase enzyme‘s inhibition. John Wiley & Sons, Inc 2023 Article PeerReviewed text en http://ir.unimas.my/id/eprint/43692/3/Unlocking.pdf Dayang Nurul Anisa, Abang Heilman and Audrey Yong, Chee Hui and Vivien Jong, Yi Mian and Fasihuddin Badruddin, Ahmad and Lim, Pei Cee and Johnson, Stanslas and Nor Hisam, Zamakshshari (2023) Unlocking the Antibacterial Potential of Xanthone from Calophyllum Species : Inhibition of Nucleic Acid Synthesis. ChemistrySelect, 8. pp. 1-18. ISSN 2365-6549 https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/slct.202302737 doi.org/10.1002/slct.202302737 |
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Q Science (General) QD Chemistry R Medicine (General) Dayang Nurul Anisa, Abang Heilman Audrey Yong, Chee Hui Vivien Jong, Yi Mian Fasihuddin Badruddin, Ahmad Lim, Pei Cee Johnson, Stanslas Nor Hisam, Zamakshshari Unlocking the Antibacterial Potential of Xanthone from Calophyllum Species : Inhibition of Nucleic Acid Synthesis |
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Plants are valuable resources for the development of novel
pharmaceutical products. The increasing threat to global health caused by antibiotic resistance remains a serious concern,driven a need to discover and evaluate novel anti-bacterial agents. Calophyllum species are known for having excellent biological activity due to its secondary metabolites, such as xanthone. Numerous xanthones have been found to possess anti-bacterial properties that are effective against plant pathogens,hence can be applied to fight human pathogens. Topoisomerase enzymes (DNA gyrase and topoisomerase IV) are DNA metabolism enzymes that possess distinct roles as unlinking enzymes during DNA replication. Nucleic acid synthesis inhibition reduces bacteria proliferation through the inhibition of topoisomerase enzymes that are essential for bacterial growth. The xanthone isolated from Calophyllum and
its anti-bacterial were discussed in this review. Besides,
molecular docking simulations were applied to explore the
potential binding mode of xanthones to DNA metabolism
enzymes. The docking study displayed that biscaloxanthone is a good topoisomerase enzymes inhibitor compared to their cocystalize ligand, novobiocin and BDBM50198240. The complied information and molecular docking simulations suggested that xanthone isolated possesses potential anti-bacterial agents inhibiting nucleic acid synthesis. Besides, it suggested that the anti-microbial activity of xanthone contributes from the topoisomerase
enzyme‘s inhibition. |
format |
Article |
author |
Dayang Nurul Anisa, Abang Heilman Audrey Yong, Chee Hui Vivien Jong, Yi Mian Fasihuddin Badruddin, Ahmad Lim, Pei Cee Johnson, Stanslas Nor Hisam, Zamakshshari |
author_facet |
Dayang Nurul Anisa, Abang Heilman Audrey Yong, Chee Hui Vivien Jong, Yi Mian Fasihuddin Badruddin, Ahmad Lim, Pei Cee Johnson, Stanslas Nor Hisam, Zamakshshari |
author_sort |
Dayang Nurul Anisa, Abang Heilman |
title |
Unlocking the Antibacterial Potential of Xanthone from
Calophyllum Species : Inhibition of Nucleic Acid Synthesis |
title_short |
Unlocking the Antibacterial Potential of Xanthone from
Calophyllum Species : Inhibition of Nucleic Acid Synthesis |
title_full |
Unlocking the Antibacterial Potential of Xanthone from
Calophyllum Species : Inhibition of Nucleic Acid Synthesis |
title_fullStr |
Unlocking the Antibacterial Potential of Xanthone from
Calophyllum Species : Inhibition of Nucleic Acid Synthesis |
title_full_unstemmed |
Unlocking the Antibacterial Potential of Xanthone from
Calophyllum Species : Inhibition of Nucleic Acid Synthesis |
title_sort |
unlocking the antibacterial potential of xanthone from
calophyllum species : inhibition of nucleic acid synthesis |
publisher |
John Wiley & Sons, Inc |
publishDate |
2023 |
url |
http://ir.unimas.my/id/eprint/43692/3/Unlocking.pdf http://ir.unimas.my/id/eprint/43692/ https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/slct.202302737 |
_version_ |
1787140530922061824 |
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13.160551 |