A 6-Month Open-Label Study of Vortioxetine among Cancer Patients with Major Depressive Disorder (MDD)
Objective: Vortioxetine is a monoaminergic drug with a novel multimodal mechanism of action. We investigated its efficacy on depressive symptoms, cognitive function, and quality of life among cancer patients.Methods: In this multicenter, open-label, single-arm, observational study, patients received...
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The Asian Pacific Journal of Cancer Prevention (APJCP)
2023
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my.unimas.ir.427132023-09-04T00:48:52Z http://ir.unimas.my/id/eprint/42713/ A 6-Month Open-Label Study of Vortioxetine among Cancer Patients with Major Depressive Disorder (MDD) Chong Guan, Ng Aya Ahmed, Abousheishaa Sue Yin, Low Nor Zuraida, Zainal Kai Shin, Thong Azizul, Awaluddin Tsui Huei, Loo Sapini, Yacob Nik Ruzyanei, Nik Jaafar Nur Iwana, Abdul Taib Nurul Ain, Mohamad Kamal Fuad, Ismail Wan Zamaniah, Wi RZ Other systems of medicine Objective: Vortioxetine is a monoaminergic drug with a novel multimodal mechanism of action. We investigated its efficacy on depressive symptoms, cognitive function, and quality of life among cancer patients.Methods: In this multicenter, open-label, single-arm, observational study, patients received flexible doses of Vortioxetine for a period of six months. All participants were assessed at baseline and scheduled for monitoring at weeks 2, 4, 8, 12, 16, 20, and 24. Depression severity was assessed using Montgomery-Asberg Depression Rating Scale (MADRS) and the Clinical Global Impression (CGI) scale. The Perceived Deficiency Questionnaire (PDQ-5) assessed the perceived cognitive difficulties in concentration, executive functioning, and memory. The European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire (EORTC) was used to assess the patients’ quality of life. Side effects of vortioxetine were monitored using the Antidepressant Side-Effect Checklist (ASEC). Results: Patients experienced a reduction in MADRS scores from 29.89 ± 5.997 at baseline to 11.59 ± 4.629 by Week 24. The PDQ-5 scores showed significant change from Week-4, whereas the EORTC role, emotional, and cognitive functioning scores showed a significant change from Week 2 onwards. CGI-Severity scores decreased from a baseline of 4.39 ± 0.746 to 2.41 ± 1.085 by Week 24. During the 24-Weeks of therapy, around three-quarters of the patients (73.3%) had one or more adverse events reported on the ASEC. The most frequently reported TEAEs were dry mouth, insomnia, somnolence, and headache, with more than a 30% incidence rate. Conclusion: Vortioxetine seems promising in the management of depression and enhancement of cognitive function and quality of life of cancer patients with Major Depressive Disorder. The Asian Pacific Journal of Cancer Prevention (APJCP) 2023-08 Article PeerReviewed text en http://ir.unimas.my/id/eprint/42713/3/A%206-Month.pdf Chong Guan, Ng and Aya Ahmed, Abousheishaa and Sue Yin, Low and Nor Zuraida, Zainal and Kai Shin, Thong and Azizul, Awaluddin and Tsui Huei, Loo and Sapini, Yacob and Nik Ruzyanei, Nik Jaafar and Nur Iwana, Abdul Taib and Nurul Ain, Mohamad Kamal and Fuad, Ismail and Wan Zamaniah, Wi (2023) A 6-Month Open-Label Study of Vortioxetine among Cancer Patients with Major Depressive Disorder (MDD). Asian Pacific Journal of Cancer Prevention, 24 (8). pp. 2583-2591. ISSN 2476-762X https://journal.waocp.org/?sid=Entrez:PubMed&id=pmid:37642043&key=2023.24.8.2583 DOI:10.31557/APJCP.2023.24.8.2583 |
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RZ Other systems of medicine Chong Guan, Ng Aya Ahmed, Abousheishaa Sue Yin, Low Nor Zuraida, Zainal Kai Shin, Thong Azizul, Awaluddin Tsui Huei, Loo Sapini, Yacob Nik Ruzyanei, Nik Jaafar Nur Iwana, Abdul Taib Nurul Ain, Mohamad Kamal Fuad, Ismail Wan Zamaniah, Wi A 6-Month Open-Label Study of Vortioxetine among Cancer Patients with Major Depressive Disorder (MDD) |
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Objective: Vortioxetine is a monoaminergic drug with a novel multimodal mechanism of action. We investigated its efficacy on depressive symptoms, cognitive function, and quality of life among cancer patients.Methods: In this multicenter, open-label, single-arm, observational study, patients received flexible doses of Vortioxetine for a period of six months. All participants were assessed at baseline and scheduled for monitoring at weeks 2, 4, 8, 12, 16, 20, and 24. Depression severity was assessed using Montgomery-Asberg Depression Rating Scale (MADRS) and the Clinical Global Impression (CGI) scale. The Perceived Deficiency Questionnaire (PDQ-5) assessed the perceived cognitive difficulties in concentration, executive functioning, and memory. The European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire (EORTC) was used to assess the patients’ quality of life. Side effects of vortioxetine were monitored using the Antidepressant Side-Effect Checklist (ASEC). Results: Patients experienced a reduction in MADRS scores from 29.89 ± 5.997 at baseline to 11.59 ± 4.629 by Week 24. The PDQ-5 scores showed significant change from Week-4, whereas the EORTC role, emotional, and cognitive functioning scores showed a significant change from Week 2 onwards. CGI-Severity scores decreased from a baseline of 4.39 ± 0.746 to 2.41 ± 1.085 by Week 24. During the 24-Weeks of therapy, around three-quarters of the patients (73.3%) had one or more adverse events reported on the ASEC. The most frequently reported TEAEs were dry mouth, insomnia, somnolence, and headache, with more than a 30% incidence rate. Conclusion: Vortioxetine seems promising in the management of depression and enhancement of cognitive function and quality of life of cancer patients with Major Depressive Disorder. |
format |
Article |
author |
Chong Guan, Ng Aya Ahmed, Abousheishaa Sue Yin, Low Nor Zuraida, Zainal Kai Shin, Thong Azizul, Awaluddin Tsui Huei, Loo Sapini, Yacob Nik Ruzyanei, Nik Jaafar Nur Iwana, Abdul Taib Nurul Ain, Mohamad Kamal Fuad, Ismail Wan Zamaniah, Wi |
author_facet |
Chong Guan, Ng Aya Ahmed, Abousheishaa Sue Yin, Low Nor Zuraida, Zainal Kai Shin, Thong Azizul, Awaluddin Tsui Huei, Loo Sapini, Yacob Nik Ruzyanei, Nik Jaafar Nur Iwana, Abdul Taib Nurul Ain, Mohamad Kamal Fuad, Ismail Wan Zamaniah, Wi |
author_sort |
Chong Guan, Ng |
title |
A 6-Month Open-Label Study of Vortioxetine among Cancer Patients with Major Depressive Disorder (MDD) |
title_short |
A 6-Month Open-Label Study of Vortioxetine among Cancer Patients with Major Depressive Disorder (MDD) |
title_full |
A 6-Month Open-Label Study of Vortioxetine among Cancer Patients with Major Depressive Disorder (MDD) |
title_fullStr |
A 6-Month Open-Label Study of Vortioxetine among Cancer Patients with Major Depressive Disorder (MDD) |
title_full_unstemmed |
A 6-Month Open-Label Study of Vortioxetine among Cancer Patients with Major Depressive Disorder (MDD) |
title_sort |
6-month open-label study of vortioxetine among cancer patients with major depressive disorder (mdd) |
publisher |
The Asian Pacific Journal of Cancer Prevention (APJCP) |
publishDate |
2023 |
url |
http://ir.unimas.my/id/eprint/42713/3/A%206-Month.pdf http://ir.unimas.my/id/eprint/42713/ https://journal.waocp.org/?sid=Entrez:PubMed&id=pmid:37642043&key=2023.24.8.2583 |
_version_ |
1776251364585766912 |
score |
13.160551 |