Drug Utilization Review of Potassium Chloride Injection Formulations Available in a Private Hospital in Kuching, Sarawak, Malaysia

Background: The concentrated potassium chloride injection is a high-alert medication and replacing it with a pre-mixed formulation can reduce the risks associated with its use. The aim of this study was to determine the clinical characteristics of patients receiving different potassium chloride for...

詳細記述

保存先:
書誌詳細
主要な著者: Melissa, Mohammad Hirman, Azmi, Sarriff
フォーマット: 論文
言語:English
出版事項: Penerbit Universiti Sains Malaysia 2013
主題:
オンライン・アクセス:http://ir.unimas.my/id/eprint/42674/3/DrugCopy.pdf
http://ir.unimas.my/id/eprint/42674/
http://www.mjms.usm.my/MJMSvol20no4.html
タグ: タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!
id my.unimas.ir.42674
record_format eprints
spelling my.unimas.ir.426742023-12-19T06:12:31Z http://ir.unimas.my/id/eprint/42674/ Drug Utilization Review of Potassium Chloride Injection Formulations Available in a Private Hospital in Kuching, Sarawak, Malaysia Melissa, Mohammad Hirman Azmi, Sarriff R Medicine (General) RS Pharmacy and materia medica RT Nursing Background: The concentrated potassium chloride injection is a high-alert medication and replacing it with a pre-mixed formulation can reduce the risks associated with its use. The aim of this study was to determine the clinical characteristics of patients receiving different potassium chloride formulations available at a private institution. The study also assessed the effectiveness and safety of pre-mixed formulations in the correction of hypokalaemia. Methods: This was a retrospective observational study consisting of 296 cases using concentrated and pre-mixed potassium chloride injections in 2011 in a private hospital in Kuching, Sarawak, Malaysia. Results: There were 135 (45.6%) cases that received concentrated potassium chloride, and 161 (54.4%) cases that received pre-mixed formulations. The patients’ clinical characteristics that were significantly related to the utilization of the different formulations were diagnosis (P < 0.001), potassium serum blood concentration (P < 0.05), and fluid overload risk (P < 0.05). The difference observed for the cases that achieved or maintained normokalaemia was statistically insignificant (P = 0.172). Infusion-related adverse effects were seen more in pre-mixes compared to concentrated formulations (6.8% versus 2.2%, P < 0.05). Conclusion: This study provides insight into the utilization of potassium chloride injections at this specific institution. The results support current recommendations to use pre-mixed formulations whenever possible. Keywords: potassium chloride, electrolytes, hypokalaemia, drug utilization evaluation, drug-use review Penerbit Universiti Sains Malaysia 2013-07 Article PeerReviewed text en http://ir.unimas.my/id/eprint/42674/3/DrugCopy.pdf Melissa, Mohammad Hirman and Azmi, Sarriff (2013) Drug Utilization Review of Potassium Chloride Injection Formulations Available in a Private Hospital in Kuching, Sarawak, Malaysia. The Malaysian Journal of Medical Sciences, 20 (4). pp. 47-55. ISSN 2180-4303 http://www.mjms.usm.my/MJMSvol20no4.html
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
language English
topic R Medicine (General)
RS Pharmacy and materia medica
RT Nursing
spellingShingle R Medicine (General)
RS Pharmacy and materia medica
RT Nursing
Melissa, Mohammad Hirman
Azmi, Sarriff
Drug Utilization Review of Potassium Chloride Injection Formulations Available in a Private Hospital in Kuching, Sarawak, Malaysia
description Background: The concentrated potassium chloride injection is a high-alert medication and replacing it with a pre-mixed formulation can reduce the risks associated with its use. The aim of this study was to determine the clinical characteristics of patients receiving different potassium chloride formulations available at a private institution. The study also assessed the effectiveness and safety of pre-mixed formulations in the correction of hypokalaemia. Methods: This was a retrospective observational study consisting of 296 cases using concentrated and pre-mixed potassium chloride injections in 2011 in a private hospital in Kuching, Sarawak, Malaysia. Results: There were 135 (45.6%) cases that received concentrated potassium chloride, and 161 (54.4%) cases that received pre-mixed formulations. The patients’ clinical characteristics that were significantly related to the utilization of the different formulations were diagnosis (P < 0.001), potassium serum blood concentration (P < 0.05), and fluid overload risk (P < 0.05). The difference observed for the cases that achieved or maintained normokalaemia was statistically insignificant (P = 0.172). Infusion-related adverse effects were seen more in pre-mixes compared to concentrated formulations (6.8% versus 2.2%, P < 0.05). Conclusion: This study provides insight into the utilization of potassium chloride injections at this specific institution. The results support current recommendations to use pre-mixed formulations whenever possible. Keywords: potassium chloride, electrolytes, hypokalaemia, drug utilization evaluation, drug-use review
format Article
author Melissa, Mohammad Hirman
Azmi, Sarriff
author_facet Melissa, Mohammad Hirman
Azmi, Sarriff
author_sort Melissa, Mohammad Hirman
title Drug Utilization Review of Potassium Chloride Injection Formulations Available in a Private Hospital in Kuching, Sarawak, Malaysia
title_short Drug Utilization Review of Potassium Chloride Injection Formulations Available in a Private Hospital in Kuching, Sarawak, Malaysia
title_full Drug Utilization Review of Potassium Chloride Injection Formulations Available in a Private Hospital in Kuching, Sarawak, Malaysia
title_fullStr Drug Utilization Review of Potassium Chloride Injection Formulations Available in a Private Hospital in Kuching, Sarawak, Malaysia
title_full_unstemmed Drug Utilization Review of Potassium Chloride Injection Formulations Available in a Private Hospital in Kuching, Sarawak, Malaysia
title_sort drug utilization review of potassium chloride injection formulations available in a private hospital in kuching, sarawak, malaysia
publisher Penerbit Universiti Sains Malaysia
publishDate 2013
url http://ir.unimas.my/id/eprint/42674/3/DrugCopy.pdf
http://ir.unimas.my/id/eprint/42674/
http://www.mjms.usm.my/MJMSvol20no4.html
_version_ 1787140515677863936
score 13.250246