The epidemiology of haematological cancers in Sarawak, Malaysia (1996 to 2015)

• Main Authors: Kuan, Jew Win, Anselm, Su Ting, Mastulu, Wahab, Abdullah, Hamdan, Jamilah, Hashim, Andrew, Kiyu, Ooi, Choo Huck
• Format: Article
• Language: English
• Published: BioMed Central Ltd 2023
• Subjects: RC Internal medicine; RC0254 Neoplasms. Tumors. Oncology (including Cancer); RZ Other systems of medicine
• Online Access: http://ir.unimas.my/id/eprint/42003/3/The%20epidemiol.pdf; http://ir.unimas.my/id/eprint/42003/; https://bmccancer.biomedcentral.com/articles/10.1186/s12885-023-10988-y#:~:text=Overall%20haematological%20cancers%20%E2%80%93%20incidence%20and%20CR&text=CR%20of%20haematological%20cancers%20in,time%20higher%20than%20a%20female.; https://doi.org/10.1186/s12885-023-10988-y

Background Published epidemiological studies of haematological cancers are few. Hereby we present a 20-year epidemiological data of haematological cancers in Sarawak from a population-based cancer registry. Methods Haematological cancer cases with ICD-10 coded C81-C96 and ICD-O coded /3 diagnosed from 1996 to 2015 were retrieved from Sarawak Cancer Registry. Adult was defined as those 15 years and above. Incidence rate (IR) was calculated based on yearly Sarawak citizen population stratified to age, gender, and ethnic groups. Age-standardised IR (ASR) was calculated using Segi World Standard Population. Results A total of 3,947 cases were retrieved and analysed. ASR was 10 and male predominance (IR ratio 1.32, 95%CI 1.24,1.41). Haematological cancers generally had a U-shaped distribution with lowest IR at age 10–14 years and exponential increment from age 40 years onwards, except acute lymphoblastic leukaemia (ALL) with highest IR in paediatric 2.8 versus adult 0.5. There was a significant difference in ethnic and specific categories of haematological cancers, of which, in general, Bidayuh (IR ratio 1.13, 95%CI 1.00, 1.27) and Melanau (IR ratio 0.54, 95%CI 0.45, 0.65) had the highest and lowest ethnic-specific IR, respectively, in comparison to Malay. The ASR (non-Hodgkin lymphoma, acute myeloid leukaemia, ALL, chronic myeloid leukaemia, and plasma cell neoplasm) showed a decreasing trend over the 20 years, -2.09 in general, while Hodgkin lymphoma showed an increasing trend of+2.80. There was crude rate difference between the 11 administrative divisions of Sarawak. Conclusions This study provided the IR and ASR of haematological cancers in Sarawak for comparison to other regions of the world. Ethnic diversity in Sarawak resulted in significant differences in IR and ASR.