Fatal Pediatric Melioidosis and the Role of Hyperferritinemic Sepsis-Induced Multiple-Organ Dysfunction Syndrome
Melioidosis is reported to cause a high fatality rate in children, even in the absence of risk factors for disease. The aim of this study was to identify characteristics of fatal pediatric melioidosis infection. We performed a retrospective analysis of children aged , 15 years with culture-confirmed...
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2 The American Society of Tropical Medicine and Hygiene
2022
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my.unimas.ir.406282022-12-02T03:13:21Z http://ir.unimas.my/id/eprint/40628/ Fatal Pediatric Melioidosis and the Role of Hyperferritinemic Sepsis-Induced Multiple-Organ Dysfunction Syndrome Anand, Mohan Malini, Paranchothy Sakthy, Segaran Richard Siu, Chiu Wong Yek Kee, Chor Yuwana, Podin Mong How, Ooi QR Microbiology R Medicine (General) Melioidosis is reported to cause a high fatality rate in children, even in the absence of risk factors for disease. The aim of this study was to identify characteristics of fatal pediatric melioidosis infection. We performed a retrospective analysis of children aged , 15 years with culture-confirmed melioidosis admitted to Bintulu Hospital in Sarawak, Malaysian Borneo, from January 2011 to December 2020. Forty-one children had culture-confirmed melioidosis. Nine (22%) had a fatal outcome; 8 (89%) had no predisposing risk factors. Bacteremia, septic shock, and acute respiratory distress syndrome were present in all fatalities. Demographic characteristics, presenting manifestation, and disseminated infection were not significantly associated with mortality, whereas the presence of splenomegaly, cytopenia, disseminated intravascular coagulation, and hepatobiliary dysfunction, all of which are features of hyperferritinemic sepsisinduced multiple-organ dysfunction syndrome, were associated with mortality. Hyperferritinemic sepsis-induced multiple-organ dysfunction syndrome may be a key component in the pathogenesis of fatal pediatric melioidosis. 2 The American Society of Tropical Medicine and Hygiene 2022 Article PeerReviewed text en http://ir.unimas.my/id/eprint/40628/1/Fatal%20Pediatric%20-%20Copy.pdf Anand, Mohan and Malini, Paranchothy and Sakthy, Segaran and Richard Siu, Chiu Wong and Yek Kee, Chor and Yuwana, Podin and Mong How, Ooi (2022) Fatal Pediatric Melioidosis and the Role of Hyperferritinemic Sepsis-Induced Multiple-Organ Dysfunction Syndrome. The American Journal of Tropical Medicine and Hygiene, 107 (2). pp. 393-396. ISSN 1476-1645 https://www.ajtmh.org/view/journals/tpmd/107/2/article-p393.xml doi:10.4269/ajtmh.22-0051 |
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QR Microbiology R Medicine (General) Anand, Mohan Malini, Paranchothy Sakthy, Segaran Richard Siu, Chiu Wong Yek Kee, Chor Yuwana, Podin Mong How, Ooi Fatal Pediatric Melioidosis and the Role of Hyperferritinemic Sepsis-Induced Multiple-Organ Dysfunction Syndrome |
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Melioidosis is reported to cause a high fatality rate in children, even in the absence of risk factors for disease. The aim of this study was to identify characteristics of fatal pediatric melioidosis infection. We performed a retrospective analysis of children aged , 15 years with culture-confirmed melioidosis admitted to Bintulu Hospital in Sarawak,
Malaysian Borneo, from January 2011 to December 2020. Forty-one children had culture-confirmed melioidosis. Nine
(22%) had a fatal outcome; 8 (89%) had no predisposing risk factors. Bacteremia, septic shock, and acute respiratory
distress syndrome were present in all fatalities. Demographic characteristics, presenting manifestation, and disseminated
infection were not significantly associated with mortality, whereas the presence of splenomegaly, cytopenia, disseminated intravascular coagulation, and hepatobiliary dysfunction, all of which are features of hyperferritinemic sepsisinduced multiple-organ dysfunction syndrome, were associated with mortality. Hyperferritinemic sepsis-induced
multiple-organ dysfunction syndrome may be a key component in the pathogenesis of fatal pediatric melioidosis. |
format |
Article |
author |
Anand, Mohan Malini, Paranchothy Sakthy, Segaran Richard Siu, Chiu Wong Yek Kee, Chor Yuwana, Podin Mong How, Ooi |
author_facet |
Anand, Mohan Malini, Paranchothy Sakthy, Segaran Richard Siu, Chiu Wong Yek Kee, Chor Yuwana, Podin Mong How, Ooi |
author_sort |
Anand, Mohan |
title |
Fatal Pediatric Melioidosis and the Role of Hyperferritinemic Sepsis-Induced Multiple-Organ Dysfunction Syndrome |
title_short |
Fatal Pediatric Melioidosis and the Role of Hyperferritinemic Sepsis-Induced Multiple-Organ Dysfunction Syndrome |
title_full |
Fatal Pediatric Melioidosis and the Role of Hyperferritinemic Sepsis-Induced Multiple-Organ Dysfunction Syndrome |
title_fullStr |
Fatal Pediatric Melioidosis and the Role of Hyperferritinemic Sepsis-Induced Multiple-Organ Dysfunction Syndrome |
title_full_unstemmed |
Fatal Pediatric Melioidosis and the Role of Hyperferritinemic Sepsis-Induced Multiple-Organ Dysfunction Syndrome |
title_sort |
fatal pediatric melioidosis and the role of hyperferritinemic sepsis-induced multiple-organ dysfunction syndrome |
publisher |
2 The American Society of Tropical Medicine and Hygiene |
publishDate |
2022 |
url |
http://ir.unimas.my/id/eprint/40628/1/Fatal%20Pediatric%20-%20Copy.pdf http://ir.unimas.my/id/eprint/40628/ https://www.ajtmh.org/view/journals/tpmd/107/2/article-p393.xml |
_version_ |
1751540638058283008 |
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13.160551 |