Phytochemicals from Calophyllum canum Hook f. ex T. Anderson and their neuroprotective effects
Previous phytochemical investigations reported that Calophyllum spp have biosynthesized a wide range of bioactive phenolics such as xanthones and coumarins. The phytochemical study conducted on the stem bark of C. canum has led to the isolation of eight trioxygenated xanthones namely: 5-methoxytrape...
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2022
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Online Access: | http://ir.unimas.my/id/eprint/39302/3/Phytochemicals%20-%20Copy.pdf http://ir.unimas.my/id/eprint/39302/ https://www.tandfonline.com/doi/full/10.1080/14786419.2022.2116021?scroll=top&needAccess=true https://doi.org/10.1080/14786419.2022.2116021 |
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my.unimas.ir.393022022-08-24T23:51:33Z http://ir.unimas.my/id/eprint/39302/ Phytochemicals from Calophyllum canum Hook f. ex T. Anderson and their neuroprotective effects Pin Fen, Chua Mas Atikah, Lizazman Vivien Mian Jong, Yii William K., Lim Thiruventhan, Karunakaran Q Science (General) QD Chemistry RZ Other systems of medicine Previous phytochemical investigations reported that Calophyllum spp have biosynthesized a wide range of bioactive phenolics such as xanthones and coumarins. The phytochemical study conducted on the stem bark of C. canum has led to the isolation of eight trioxygenated xanthones namely: 5-methoxytrapezifolixanthone (1), 5-methoxyananixanthone (2), caloxanthone C (3), 1,5-dihydroxy-3-methoxy-4-isoprenylxanthone (4), 6-deoxyisojacareubin (5), euxanthone (6), trapezifolixanthone (7), ananixanthone (8), together with three common triterpenoids, β-sitosterol (9), friedelin (10), and stigmasterol (11). Furthermore, xanthones 1 and 2 were isolated for the first time as naturally occurring xanthones from the plant extract. The structures of these compounds were identified and elucidated using advanced spectroscopic techniques such as 1 D & 2 D NMR, MS, and FTIR. The neuroprotective property of selected compounds was tested through in vitro stroke model. Among all tested compounds, 1 µm of compounds 8, 9, and 10 showed significant neuroprotective activity via reduction of apoptosis by ∼ 50%. Taylor & Francis 2022-08-23 Article PeerReviewed text en http://ir.unimas.my/id/eprint/39302/3/Phytochemicals%20-%20Copy.pdf Pin Fen, Chua and Mas Atikah, Lizazman and Vivien Mian Jong, Yii and William K., Lim and Thiruventhan, Karunakaran (2022) Phytochemicals from Calophyllum canum Hook f. ex T. Anderson and their neuroprotective effects. NATURAL PRODUCT RESEARCH. pp. 1-7. ISSN 1478-6419 https://www.tandfonline.com/doi/full/10.1080/14786419.2022.2116021?scroll=top&needAccess=true https://doi.org/10.1080/14786419.2022.2116021 |
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Q Science (General) QD Chemistry RZ Other systems of medicine Pin Fen, Chua Mas Atikah, Lizazman Vivien Mian Jong, Yii William K., Lim Thiruventhan, Karunakaran Phytochemicals from Calophyllum canum Hook f. ex T. Anderson and their neuroprotective effects |
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Previous phytochemical investigations reported that Calophyllum spp have biosynthesized a wide range of bioactive phenolics such as xanthones and coumarins. The phytochemical study conducted on the stem bark of C. canum has led to the isolation of eight trioxygenated xanthones namely: 5-methoxytrapezifolixanthone (1), 5-methoxyananixanthone (2), caloxanthone C (3), 1,5-dihydroxy-3-methoxy-4-isoprenylxanthone (4), 6-deoxyisojacareubin (5), euxanthone (6), trapezifolixanthone (7), ananixanthone (8), together with three common triterpenoids, β-sitosterol (9), friedelin (10), and stigmasterol (11). Furthermore, xanthones 1 and 2 were isolated for the first time as naturally occurring xanthones from the plant extract. The structures of these compounds were identified and elucidated using advanced spectroscopic techniques such as 1 D & 2 D NMR, MS, and FTIR. The neuroprotective property of selected compounds was tested through in vitro stroke model. Among all tested compounds, 1 µm of compounds 8, 9, and 10 showed significant neuroprotective activity via reduction of apoptosis by ∼ 50%. |
format |
Article |
author |
Pin Fen, Chua Mas Atikah, Lizazman Vivien Mian Jong, Yii William K., Lim Thiruventhan, Karunakaran |
author_facet |
Pin Fen, Chua Mas Atikah, Lizazman Vivien Mian Jong, Yii William K., Lim Thiruventhan, Karunakaran |
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Pin Fen, Chua |
title |
Phytochemicals from Calophyllum canum Hook f. ex T. Anderson and their neuroprotective effects |
title_short |
Phytochemicals from Calophyllum canum Hook f. ex T. Anderson and their neuroprotective effects |
title_full |
Phytochemicals from Calophyllum canum Hook f. ex T. Anderson and their neuroprotective effects |
title_fullStr |
Phytochemicals from Calophyllum canum Hook f. ex T. Anderson and their neuroprotective effects |
title_full_unstemmed |
Phytochemicals from Calophyllum canum Hook f. ex T. Anderson and their neuroprotective effects |
title_sort |
phytochemicals from calophyllum canum hook f. ex t. anderson and their neuroprotective effects |
publisher |
Taylor & Francis |
publishDate |
2022 |
url |
http://ir.unimas.my/id/eprint/39302/3/Phytochemicals%20-%20Copy.pdf http://ir.unimas.my/id/eprint/39302/ https://www.tandfonline.com/doi/full/10.1080/14786419.2022.2116021?scroll=top&needAccess=true https://doi.org/10.1080/14786419.2022.2116021 |
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