Pharmacological perturbation of CXCL1 signaling alleviates neuropathogenesis in a model of HEVA71 infection

• Main Authors: Saravanan, Gunaseelan, Mohammed Zacky, Ariffin, Sanjay, Khanna, Mong, How Ooi, Perera, David, Chu, Justin Jang Hann, Chua, John Jia En
• Format: Article
• Language: English
• Published: Springer Nature 2022
• Subjects: RA0421 Public health. Hygiene. Preventive Medicine
• Online Access: http://ir.unimas.my/id/eprint/38040/1/Pharmacological%20perturbation%20of%20CXCL1.pdf; http://ir.unimas.my/id/eprint/38040/; https://www.nature.com/articles/s41467-022-28533-z

Hand, foot and mouth disease (HFMD) caused by Human Enterovirus A71 (HEVA71) infection is typically a benign infection. However, in minority of cases, children can develop severe neuropathology that culminate in fatality. Approximately 36.9% of HEVA71-related hospitalizations develop neurological co...