A Metabolic Activation Mechanism of 7H-Dibenzo[c,g]carbazole via O-Quinone. Part 2: Covalent Adducts of 7H-Dibenzo[c,g]carbazole-3,4-dione with Nucleic Acid Bases and Nucleosides

• Main Authors: Weiling, Xue, Angela, Siner, Mark, Rance, Koka, Jayasimhulu, Glenn, Talaska, David, Warshawsky
• Format: Article
• Language: English
• Published: 2002
• Subjects: Q Science (General); RC0254 Neoplasms. Tumors. Oncology (including Cancer); RZ Other systems of medicine
• Online Access: http://ir.unimas.my/id/eprint/37917/1/A%20Metabolic%20Activation%20Mechanism.pdf; http://ir.unimas.my/id/eprint/37917/; https://hero.epa.gov/hero/index.cfm/reference/details/reference_id/2246824

7H-Dibenzo[c,g]carbazole (DBC) is a potent multispecies, multisite carcinogen present in the environment. The metabolic activation pathways of DBC are not completely known. It is hypothesized that DBC may be metabolically activated by oxidation to the reactive Michael acceptor o-quinones, which can...