Synthesis and Characterization of Multifunctional Nanostructures Derived from Native Sago Starch for Potential Biomedical Applications

• Main Author: Asniar, Salim
• Format: Thesis
• Language: English
• Published: Universiti Malaysia Sarawak (UNIMAS) 2020
• Subjects: Q Science (General); QD Chemistry
• Online Access: http://ir.unimas.my/id/eprint/33141/1/Asniar%20Binti%20Salim%20ft.pdf; http://ir.unimas.my/id/eprint/33141/

This study reports the potential application of hydroxypropyl starch and starch acetate nanoparticles as a controlled release nanocarrier for piperine. Hydroxypropyl starch and starch acetate were synthesized by modifying sago starch with hydroxypropylation and acetylation reaction. Hydroxypropyl starch nanoparticles with mean particle sizes of 110 nm were obtained by controlled precipitation through drop-wise addition of dissolved hydroxypropyl starch solution into excess absolute ethanol. Meanwhile, starch acetate with mean particle sizes of 140 nm was also successfully obtained by the same manner. Piperine was loaded onto hydroxypropyl starch nanoparticles, starch acetate nanoparticles, and native starch nanoparticles via the in-situ nanoprecipitation process. Hydroxypropyl starch nanoparticles and starch acetate nanoparticles achieved higher piperine loading capacity as compared to native starch nanoparticles with the maximum loading capacity of 0.46, 0.50, and 0.33 mg.mg-1 , respectively. Hydroxypropyl starch nanoparticles was able to retain piperine in the simulated stomach pH (1.2) where it was released in a slow and sustained manner within 24 hours, while piperine was release from starch acetate nanoparticles over a period of 28 hours in the simulated blood pH (7.4). On the other hand, the release rates of piperine from native starch nanoparticles were faster, whereby 96% of piperine was released within 16 hours at all pH tested in the same manner.