Comparing quality of life and treatment satisfaction between patients on warfarin and direct oral anticoagulants : a cross-sectional study
Introduction and aim: Patient quality of life (QOL) while on long-term oral anticoagulant therapy has been receiving greater attention in recent years due to the increase in life expectancy brought about by advances in medical care. This study aimed to compare the QOL, treatment satisfaction, hospit...
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my.unimas.ir.264022021-04-28T21:52:40Z http://ir.unimas.my/id/eprint/26402/ Comparing quality of life and treatment satisfaction between patients on warfarin and direct oral anticoagulants : a cross-sectional study Ng, Diana Leh-Ching Gan, Gin Gin Chai, Chee Shee Chee, Kok Han Tan, Kok Leng Tan, Seng Beng Bee, Ping Chong R Medicine (General) RZ Other systems of medicine Introduction and aim: Patient quality of life (QOL) while on long-term oral anticoagulant therapy has been receiving greater attention in recent years due to the increase in life expectancy brought about by advances in medical care. This study aimed to compare the QOL, treatment satisfaction, hospitalization and bleeding rate in patients on long-term warfarin versus direct oral anticoagulants (DOAC). Methods: This was a cross-sectional study of patients with non-valvular atrial fibrillation (NVAF) or venous thromboembolism (VTE) on long-term anticoagulant therapy attending the cardiology clinic and anticoagulation clinic of the University Malaya Medical Centre from July 1, 2016, to June 30, 2018. Patient QOL was assessed by using the Short Form 12 Health Survey (SF12), while treatment satisfaction was assessed by using the Perception of Anticoagulation Treatment Questionnaire 2 (PACT-Q2). Results: A total of 208 patients were recruited; 52.4% received warfarin and 47.6% received DOAC. There was no significant difference in QOL between warfarin and DOAC based on SF12 (physical QOL, P=0.083; mental QOL, P=0.665). Nevertheless, patients in the DOAC group were significantly more satisfied with their treatment compared to the warfarin group based on PACT-Q2 (P=0.004). The hospitalisation rate was significantly higher in the warfarin group than the DOAC group (15.6% versus 3.0%, P=0.002). Clinically relevant minor bleeds and severe bleeding events were non-significantly higher in the warfarin group than the DOAC group (66.7% versus 40.0%, P=0.069). Conclusion: Compared to warfarin, treatment of NVAF and VTE with DOAC showed comparable QOL, higher treatment satisfaction, lesser hospitalization, and a non-significant trend toward fewer bleeding episodes. Dovepress 2019-08-14 Article PeerReviewed text en http://ir.unimas.my/id/eprint/26402/1/Comparing%20quality.pdf Ng, Diana Leh-Ching and Gan, Gin Gin and Chai, Chee Shee and Chee, Kok Han and Tan, Kok Leng and Tan, Seng Beng and Bee, Ping Chong (2019) Comparing quality of life and treatment satisfaction between patients on warfarin and direct oral anticoagulants : a cross-sectional study. Patient Preference and Adherence, 13. pp. 1363-1373. ISSN 1177-889X https://www.dovepress.com/comparing-quality-of-life-and-treatment-satisfaction-between-patients--peer-reviewed-article-PPA DOI https://doi.org/10.2147/PPA.S204246 |
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R Medicine (General) RZ Other systems of medicine Ng, Diana Leh-Ching Gan, Gin Gin Chai, Chee Shee Chee, Kok Han Tan, Kok Leng Tan, Seng Beng Bee, Ping Chong Comparing quality of life and treatment satisfaction between patients on warfarin and direct oral anticoagulants : a cross-sectional study |
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Introduction and aim: Patient quality of life (QOL) while on long-term oral anticoagulant therapy has been receiving greater attention in recent years due to the increase in life expectancy brought about by advances in medical care. This study aimed to compare the QOL, treatment satisfaction, hospitalization and bleeding rate in patients on long-term warfarin versus direct oral anticoagulants (DOAC). Methods: This was a cross-sectional study of patients with non-valvular atrial fibrillation (NVAF) or venous thromboembolism (VTE) on long-term anticoagulant therapy attending the cardiology clinic and anticoagulation clinic of the University Malaya Medical Centre from July 1, 2016, to June 30, 2018. Patient QOL was assessed by using the Short Form 12
Health Survey (SF12), while treatment satisfaction was assessed by using the Perception of Anticoagulation Treatment Questionnaire 2 (PACT-Q2).
Results: A total of 208 patients were recruited; 52.4% received warfarin and 47.6% received DOAC. There was no significant difference in QOL between warfarin and DOAC based on SF12 (physical QOL, P=0.083; mental QOL, P=0.665). Nevertheless, patients in the DOAC
group were significantly more satisfied with their treatment compared to the warfarin group based on PACT-Q2 (P=0.004). The hospitalisation rate was significantly higher in the warfarin group than the DOAC group (15.6% versus 3.0%, P=0.002). Clinically relevant minor bleeds and severe bleeding events were non-significantly higher in the warfarin group than the DOAC group (66.7% versus 40.0%, P=0.069).
Conclusion: Compared to warfarin, treatment of NVAF and VTE with DOAC showed comparable QOL, higher treatment satisfaction, lesser hospitalization, and a non-significant trend toward fewer bleeding episodes. |
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Article |
author |
Ng, Diana Leh-Ching Gan, Gin Gin Chai, Chee Shee Chee, Kok Han Tan, Kok Leng Tan, Seng Beng Bee, Ping Chong |
author_facet |
Ng, Diana Leh-Ching Gan, Gin Gin Chai, Chee Shee Chee, Kok Han Tan, Kok Leng Tan, Seng Beng Bee, Ping Chong |
author_sort |
Ng, Diana Leh-Ching |
title |
Comparing quality of life and treatment satisfaction between patients on warfarin and direct oral anticoagulants : a cross-sectional study |
title_short |
Comparing quality of life and treatment satisfaction between patients on warfarin and direct oral anticoagulants : a cross-sectional study |
title_full |
Comparing quality of life and treatment satisfaction between patients on warfarin and direct oral anticoagulants : a cross-sectional study |
title_fullStr |
Comparing quality of life and treatment satisfaction between patients on warfarin and direct oral anticoagulants : a cross-sectional study |
title_full_unstemmed |
Comparing quality of life and treatment satisfaction between patients on warfarin and direct oral anticoagulants : a cross-sectional study |
title_sort |
comparing quality of life and treatment satisfaction between patients on warfarin and direct oral anticoagulants : a cross-sectional study |
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Dovepress |
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2019 |
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http://ir.unimas.my/id/eprint/26402/1/Comparing%20quality.pdf http://ir.unimas.my/id/eprint/26402/ https://www.dovepress.com/comparing-quality-of-life-and-treatment-satisfaction-between-patients--peer-reviewed-article-PPA |
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