Styryl Lactones from Roots and Barks Goniothalamus lanceolatus
A new styryl lactone, 5R,6R-5-hydroxy-6-styryltetrahydropyrane-2-one 2 was isolated from the roots of an endemic Goniothalamus lanceolatus Miq. of Sarawak, Malaysia. Furthermore, seven previously undescribed diastereomers, 5R,6R-5-hydroxygoniothalamin 3, 5R,6R-5-acetylgoniothalamin 4, 6S,7S,8Sgonio...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publications
2018
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| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/25910/1/Styryl%20Lactones.pdf http://ir.unimas.my/id/eprint/25910/ https://journals.sagepub.com/doi/abs/10.1177/1934578X1801301203 |
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| Summary: | A new styryl lactone, 5R,6R-5-hydroxy-6-styryltetrahydropyrane-2-one 2 was isolated from the roots of an endemic Goniothalamus lanceolatus Miq. of
Sarawak, Malaysia. Furthermore, seven previously undescribed diastereomers, 5R,6R-5-hydroxygoniothalamin 3, 5R,6R-5-acetylgoniothalamin 4, 6S,7S,8Sgoniodiol-7-monoacetate 5, 6S,7S,8S-goniodiol-8-monoacetate 6, goniofupyrone B 7, deoxygoniopypyrone B 8 and 1S,5S,7R,8S,3-endo,7-endo-(+)-8-epi-9-
deoxygoniopypyrone acetate 9, along with six known styryl lactones (1, 10-15) were also isolated and characterized. 6S-goniothalamin 1 is reported for the
first time from a Goniothalamus species. 1, 11 and 12 showed cytotoxic activity against human colon and lung cancer cell lines with IC50 values ranging from
2.38-7.59 µM |
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