Association between Clinical Parameters and CRT Response

• Main Authors: Asri, Bin Said, Shu, F.E.P., Voon, C.Y., Ho, K. H., Tan, C. T., Koh, K. T,, Oon, Y.Y., Cham, Y. L., Nor Hanim, M. A., Khiew, N.Z., Fong, A.Y.Y., Ong, T.K.
• Format: E-Article
• Language: English
• Published: Elsevier 2018
• Subjects: R Medicine (General); RC Internal medicine
• Online Access: http://ir.unimas.my/id/eprint/22937/1/Association%20between%20Clinical%20Parameters%20and%20CRT%20Response.pdf; http://ir.unimas.my/id/eprint/22937/; https://www.journals.elsevier.com/international-journal-of-cardiology

Background: CRT is indicated for patients with severely impaired left ventricular systolic function and ventricular dyssynchrony who remain symptomatic despite optimal medical therapy. CRT is an expensive treatment with a significant non-responder rate. Objective: To ensure appropriate use of this treatment modality, we decided to investigate whether clinical parameters can predict response to CRT in our patients. Methods: We retrospectively reviewed all CRT patients under responder based on pre-specified ECHO and clinical criteria. An ECHO response would be: relative improvement from baseline left ventricular ejection fraction (EF) of N 15%; and a decrease in End Diastolic Volume index (EDVi) or End Systolic Volume index (ESVi) of N 15%. Clinical response was defined as an improvement of at least 1 NYHA functional class. Patients who fulfil both ECHO and clinical criteria are considered responders our follow-up since 2014. We classified them as responder or non.