Melioidosis in Malaysia : Incidence, Clinical Challenges, and Advances in Understanding Pathogenesis
Malaysia is an endemic hot spot for melioidosis; however,a comprehensive picture of the burden of disease, clinical presentations, and challenges faced in diagnosis and treatment of melioidosis is not available. This review provides a nonexhaustive overview of epidemiological data, clinical studies,...
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Online Access: | http://ir.unimas.my/id/eprint/19819/1/Melioidosis.pdf http://ir.unimas.my/id/eprint/19819/ http://www.mdpi.com/journal/tropicalmed |
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my.unimas.ir.198192021-04-28T22:28:14Z http://ir.unimas.my/id/eprint/19819/ Melioidosis in Malaysia : Incidence, Clinical Challenges, and Advances in Understanding Pathogenesis Nathan, Sheila Chieng, Sylvia Kingsley, Paul Vijay Mohan, Anand Podin, Yuwana Ooi, Mong How Mariappan, Vanitha Vellasamy, Kumutha Malar Vadivelu, Jamuna Daim, Sylvia Soon-Hin, How QR Microbiology R Medicine (General) Malaysia is an endemic hot spot for melioidosis; however,a comprehensive picture of the burden of disease, clinical presentations, and challenges faced in diagnosis and treatment of melioidosis is not available. This review provides a nonexhaustive overview of epidemiological data, clinical studies, risk factors, and mortality rates from available literature and case reports. Clinical patterns of melioidosis are generally consistent with those from South and Southeast Asia in terms of common primary presentations with diabetes as a major risk factor. Early diagnosis and appropriate management of Malaysian patients is a key limiting factor, which needs to be addressed to reduce serious complications and high mortality and recurrence rates. Promoting awareness among the local healthcare personnel is crucial to improving diagnostics and early treatment, as well as educating the Malaysian public on disease symptoms and risk factors. A further matter of urgency is the need to make this a notifiable disease and the establishment of a national melioidosis registry. We also highlight local studies on the causative agent, Burkholderia pseudomallei, with regards to bacteriology and identification of virulence factors as well as findings from host–pathogen interaction studies. Collectively, these studies have uncovered new correlations and insights for further understanding of the disease. MDPI 2018-02-27 Article PeerReviewed text en http://ir.unimas.my/id/eprint/19819/1/Melioidosis.pdf Nathan, Sheila and Chieng, Sylvia and Kingsley, Paul Vijay and Mohan, Anand and Podin, Yuwana and Ooi, Mong How and Mariappan, Vanitha and Vellasamy, Kumutha Malar and Vadivelu, Jamuna and Daim, Sylvia and Soon-Hin, How (2018) Melioidosis in Malaysia : Incidence, Clinical Challenges, and Advances in Understanding Pathogenesis. Tropical Medicine and Infectious Disease, 3 (1). ISSN 2414-6366 http://www.mdpi.com/journal/tropicalmed Doi: 10.3390/tropicalmed3010025 |
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QR Microbiology R Medicine (General) Nathan, Sheila Chieng, Sylvia Kingsley, Paul Vijay Mohan, Anand Podin, Yuwana Ooi, Mong How Mariappan, Vanitha Vellasamy, Kumutha Malar Vadivelu, Jamuna Daim, Sylvia Soon-Hin, How Melioidosis in Malaysia : Incidence, Clinical Challenges, and Advances in Understanding Pathogenesis |
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Malaysia is an endemic hot spot for melioidosis; however,a comprehensive picture of the burden of disease, clinical presentations, and challenges faced in diagnosis and treatment of melioidosis is not available. This review provides a nonexhaustive overview of epidemiological data, clinical studies, risk factors, and mortality rates from available literature and case reports. Clinical patterns of melioidosis are generally consistent with those from South and Southeast Asia in terms of common primary presentations with diabetes as a major risk factor. Early diagnosis and appropriate management of Malaysian patients is a key limiting factor, which needs to be addressed
to reduce serious complications and high mortality and recurrence rates. Promoting awareness among the local healthcare personnel is crucial to improving diagnostics and early treatment, as well as educating the Malaysian public on disease symptoms and risk factors. A further matter of urgency is the need to make this a notifiable disease and the establishment of a national melioidosis registry. We also highlight local studies on the causative agent, Burkholderia pseudomallei, with regards to bacteriology and identification of virulence factors as well as findings from host–pathogen interaction studies. Collectively, these studies have uncovered new correlations and insights for further understanding of the disease. |
format |
Article |
author |
Nathan, Sheila Chieng, Sylvia Kingsley, Paul Vijay Mohan, Anand Podin, Yuwana Ooi, Mong How Mariappan, Vanitha Vellasamy, Kumutha Malar Vadivelu, Jamuna Daim, Sylvia Soon-Hin, How |
author_facet |
Nathan, Sheila Chieng, Sylvia Kingsley, Paul Vijay Mohan, Anand Podin, Yuwana Ooi, Mong How Mariappan, Vanitha Vellasamy, Kumutha Malar Vadivelu, Jamuna Daim, Sylvia Soon-Hin, How |
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Nathan, Sheila |
title |
Melioidosis in Malaysia : Incidence, Clinical Challenges, and Advances in Understanding Pathogenesis |
title_short |
Melioidosis in Malaysia : Incidence, Clinical Challenges, and Advances in Understanding Pathogenesis |
title_full |
Melioidosis in Malaysia : Incidence, Clinical Challenges, and Advances in Understanding Pathogenesis |
title_fullStr |
Melioidosis in Malaysia : Incidence, Clinical Challenges, and Advances in Understanding Pathogenesis |
title_full_unstemmed |
Melioidosis in Malaysia : Incidence, Clinical Challenges, and Advances in Understanding Pathogenesis |
title_sort |
melioidosis in malaysia : incidence, clinical challenges, and advances in understanding pathogenesis |
publisher |
MDPI |
publishDate |
2018 |
url |
http://ir.unimas.my/id/eprint/19819/1/Melioidosis.pdf http://ir.unimas.my/id/eprint/19819/ http://www.mdpi.com/journal/tropicalmed |
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13.18916 |