Synthesis, modification, characterization and biological activity of 3-hydroxybenzaldehydesalicylhydrazide [Sintesis, modifikasi, pencirian dan aktiviti biologi 3-hidroksibenzaldehidesalisilhidrazida]

• Main Authors: Nornadia, Jasin, Meng, Guan Tay, Hashimatul Fatma, Hashim
• Format: Article
• Language: English
• Published: Malaysian Society of Analytical Sciences 2017
• Subjects: QD Chemistry
• Online Access: http://ir.unimas.my/id/eprint/18936/7/SYNTHESIS.pdf; http://ir.unimas.my/id/eprint/18936/; http://www.ukm.my/mjas/mjas2018/; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85032027821&doi=10.17576%2fmjas-2017-2105-24&partnerID=40&md5=e7bdfc217e5a78ba945222607aca97df

A series of hydrazone Schiff base (compounds S, S8, S10 and S12) were synthesized by condensation reaction of salicylhydrazide with 3-hydroxybenzaldehyde, 3-(octyloxy)benzaldehyde, 3-(decyloxy)benzaldehyde and 3-(dodecyloxy) benzaldehyde, respectively. Herein, the addition of alkane numbers are reported using suscessful Williamson etherification method by reacting 3-hydroxybenzaldehyde with bromooctane, bromodecane and bromododecane, respectively. All compounds were characterised using Fourier Transform Infrared and 1H Nuclear Mangnetic Resonance spectroscopic. The compounds were assayed to antibacterial activity against Gram-positive and Gram-negative bacteria using Bacillus cereus and Escherichia coli by disc diffusion method. Interestingly, among the compounds tested S8 showed a strong inhibition against Escherichia coli and none of the compounds tested show significant result against Bacillus cereus.