AIM2 Inflammasome-Mediated Pyroptosis in Enterovirus A71-Infected Neuronal Cells Restricts Viral Replication

• Main Authors: Yogarajah, Thinesshwary, Ong, Kienchai, David, Perera, Wong, Kumthong
• Format: E-Article
• Language: English
• Published: Nature Publishing Group 2017
• Subjects: GE Environmental Sciences
• Online Access: http://ir.unimas.my/id/eprint/17285/1/AIM2%20Inflammasome-Mediated%20Pyroptosis%20in%20Enterovirus%20A71%20%28abstract%29.pdf; http://ir.unimas.my/id/eprint/17285/; http://www.nature.com/scientificreports

Encephalomyelitis is a well-known complication of hand, foot, and mouth disease (HFMD) due to Enterovirus 71 (EV71) infection. Viral RNA/antigens could be detected in the central nervous system (CNS) neurons in fatal encephalomyelitis but the mechanisms of neuronal cell death is not clearly understo...