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Cloning and expression of prM and it's use to distinguish host immune responses against dengue virus and Japanese encephalitis virus infections

All flaviviruses share common epitopes on the envelope protein (E) that results in extensive crossreactions in serological tests. /this makes it difficult to distinguish between immune responses against dengue virus (DENV) and Japanese encephalitis virus (JEV), particularly in regions where these vi...

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Main Author: Wang, Seok Mui
Format: Thesis
Language:English
Published: 2001
Subjects:
RA Public aspects of medicine
Online Access:http://ir.unimas.my/id/eprint/16585/1/Wong%20Seok%20ft.pdf
http://ir.unimas.my/id/eprint/16585/
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spelling my.unimas.ir.165852023-11-21T05:21:20Z http://ir.unimas.my/id/eprint/16585/ Cloning and expression of prM and it's use to distinguish host immune responses against dengue virus and Japanese encephalitis virus infections Wang, Seok Mui RA Public aspects of medicine All flaviviruses share common epitopes on the envelope protein (E) that results in extensive crossreactions in serological tests. /this makes it difficult to distinguish between immune responses against dengue virus (DENV) and Japanese encephalitis virus (JEV), particularly in regions where these viruses co-circulate. We have demonstrated that DENV and JEV have unique epitopes on the prM. By detecting prM specific IgG, it is possible to distinguish between DENV and JEV infection. Current approach used in seroanalysis of DENV and JEV infections is based on antigens derived from the whole viral antigens. 2001 Thesis NonPeerReviewed text en http://ir.unimas.my/id/eprint/16585/1/Wong%20Seok%20ft.pdf Wang, Seok Mui (2001) Cloning and expression of prM and it's use to distinguish host immune responses against dengue virus and Japanese encephalitis virus infections. Masters thesis, Universiti Malaysia Sarawak, (UNIMAS).
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
language English
topic RA Public aspects of medicine
spellingShingle RA Public aspects of medicine
Wang, Seok Mui
Cloning and expression of prM and it's use to distinguish host immune responses against dengue virus and Japanese encephalitis virus infections
description All flaviviruses share common epitopes on the envelope protein (E) that results in extensive crossreactions in serological tests. /this makes it difficult to distinguish between immune responses against dengue virus (DENV) and Japanese encephalitis virus (JEV), particularly in regions where these viruses co-circulate. We have demonstrated that DENV and JEV have unique epitopes on the prM. By detecting prM specific IgG, it is possible to distinguish between DENV and JEV infection. Current approach used in seroanalysis of DENV and JEV infections is based on antigens derived from the whole viral antigens.
format Thesis
author Wang, Seok Mui
author_facet Wang, Seok Mui
author_sort Wang, Seok Mui
title Cloning and expression of prM and it's use to distinguish host immune responses against dengue virus and Japanese encephalitis virus infections
title_short Cloning and expression of prM and it's use to distinguish host immune responses against dengue virus and Japanese encephalitis virus infections
title_full Cloning and expression of prM and it's use to distinguish host immune responses against dengue virus and Japanese encephalitis virus infections
title_fullStr Cloning and expression of prM and it's use to distinguish host immune responses against dengue virus and Japanese encephalitis virus infections
title_full_unstemmed Cloning and expression of prM and it's use to distinguish host immune responses against dengue virus and Japanese encephalitis virus infections
title_sort cloning and expression of prm and it's use to distinguish host immune responses against dengue virus and japanese encephalitis virus infections
publishDate 2001
url http://ir.unimas.my/id/eprint/16585/1/Wong%20Seok%20ft.pdf
http://ir.unimas.my/id/eprint/16585/
_version_ 1783883476308590592
score 13.160551

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