Toxicity screening analysis of dipropyl phthalate, DPP on early vertebrate development
Phthalates are most frequently used chemical in industries to make plasticizers and polymer additive in gel capsules, cosmetic, and other personal care products. This study was initiated to enhance our insight on the health and environmental impact on Dipropyl phthalate, DPP - one of the phthalat...
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| Main Author: | |
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| Format: | Final Year Project Report |
| Language: | English |
| Published: |
Universiti Malaysia Sarawak, (UNIMAS)
2016
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| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/15471/3/Nur%20Qistina%20Diyana.pdf http://ir.unimas.my/id/eprint/15471/ |
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| Summary: | Phthalates are most frequently used chemical in industries to make plasticizers and polymer
additive in gel capsules, cosmetic, and other personal care products. This study was initiated
to enhance our insight on the health and environmental impact on Dipropyl phthalate, DPP
- one of the phthalate family. In this study, the effects of dipropyl phthalate on the
development of zebrafish embryos and early larval stages were investigated. Eggs were
exposed to dipropyl phthalate toxic started from 4 to 96-hour post fertilization (hpf), and
defects of the zebrafish larvae examined at 96 hpf. Toxicological endpoints like mortality,
hatching delay, pericardial edema, yolk sac edema, non-inflated swim bladder, deformation
of the tail, blood island, and mobility were recorded. The LC5o calculated to be 7.546 mg/L.
These results suggest that dipropyl phthalate could induce a dose-dependent toxicity in
embryos, which hinders normal development. |
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