Structure-to-Function Computational Prediction of a Subset of Ribosomal Proteins for the Small Ribosome Subunit
Extra-ribosomal functions of ribosomal proteins have been widely accepted albeit an incomplete understanding of these roles. Standard experimental studies have limited usefulness in defining the complete biological significance of ribosomal proteins. An alternative strategy is via in silico analys...
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| Main Authors: | , |
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| Format: | E-Article |
| Language: | English |
| Published: |
International Academy Publishing (IAP)
2015
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| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/13008/1/Structure-to-Function%20Computational%20Prediction%20of%20a%20Subset%20of%20Ribosomal%20Protiens%20%28abstract%29.pdf http://ir.unimas.my/id/eprint/13008/ |
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| Summary: | Extra-ribosomal functions of ribosomal proteins have been widely accepted albeit an incomplete
understanding of these roles. Standard experimental studies have limited usefulness in defining the
complete biological significance of ribosomal proteins. An alternative strategy is via in silico analysis. Here,
we sought a sequence-to-structure-to-function approach to computationally predict the extra-ribosomal
functions of a subset of ribosomal proteins of the small ribosome subunit, namely RPS12, RPS19, RPS20 and
RPS24. Three-dimensional structure constructed from amino acid sequence was precisely matched with
structural neighbours to extrapolate possible functions. Our analysis reveals new logical roles for these
ribosomal proteins, of which represent important information for planning experimental and further in
silico studies to elucidate their physiological roles. |
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