Gender-specific association of NFKBIA promoter polymorphisms with the risk of sporadic colorectal cancer

• Main Authors: Tan, Shing Cheng, Mohd Shafi’i, Mohd Suzairi, Abdul Aziz, Ahmad Aizat, Mustapha, Mohd Aminudin, Siti Nurfatimah, Mohd Shahpudin, Venkata Murali, Krishna Bhavaraju, Biswal, Biswal Mohan, Ravindran, Ankathil
• Format: Article
• Language: English
• Published: Springer US 2013
• Subjects: RB Pathology; RC Internal medicine
• Online Access: http://ir.unimas.my/id/eprint/11980/1/Gender-specific%20association%20of%20NFKBIA%20promoter%20polymorphisms%20%28abstract%29.pdf; http://ir.unimas.my/id/eprint/11980/; http://link.springer.com/article/10.1007%2Fs12032-013-0693-6

The inhibitory protein IκBα, encoded by the NFKBIA gene, plays an important role in regulating the activity of nuclear factor-kappa B, a transcription factor which has been implicated in the initiation and progression of cancers. This study aimed to evaluate the association of NFKBIA −826C>T (rs2...