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Synthesis, characterization and antibacterial activity of bis thiourea derivatives

A series of bisthiourea derivatives were succesfully synthesized by reaction of benzene-1, 4 dicarbonyl isothiocyanate intermediates and isophthaloyl dichloride, with a series of aromatic amine at ortho, meta and para position. The structure of synthesised compound characterized by infra-red spect...

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Main Author: Jayakumar, Ponniasalan
Format: Final Year Project Report
Language:English
Published: Universiti Malaysia Sarawak, (UNIMAS) 2015
Subjects:
RV Botanic, Thomsonian, and eclectic medicine
Online Access:http://ir.unimas.my/id/eprint/11053/9/Synthesis%2C%20Characterization..%28fulltext%29.pdf
http://ir.unimas.my/id/eprint/11053/
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spelling my.unimas.ir.110532023-06-28T07:04:38Z http://ir.unimas.my/id/eprint/11053/ Synthesis, characterization and antibacterial activity of bis thiourea derivatives Jayakumar, Ponniasalan RV Botanic, Thomsonian, and eclectic medicine A series of bisthiourea derivatives were succesfully synthesized by reaction of benzene-1, 4 dicarbonyl isothiocyanate intermediates and isophthaloyl dichloride, with a series of aromatic amine at ortho, meta and para position. The structure of synthesised compound characterized by infra-red spectroscopy (FTIR), 1H Nuclear magnetic resonances, and 13C Nuclear magnetic resonances. The synthesised compounds were screened for their antibacterial properties using Gram-negative bacteria Escherichia coli (E.coli) by using disc diffusion method. All of synthesized series showed negative results towards antibacterial activity. Universiti Malaysia Sarawak, (UNIMAS) 2015 Final Year Project Report NonPeerReviewed text en http://ir.unimas.my/id/eprint/11053/9/Synthesis%2C%20Characterization..%28fulltext%29.pdf Jayakumar, Ponniasalan (2015) Synthesis, characterization and antibacterial activity of bis thiourea derivatives. [Final Year Project Report] (Unpublished)
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
language English
topic RV Botanic, Thomsonian, and eclectic medicine
spellingShingle RV Botanic, Thomsonian, and eclectic medicine
Jayakumar, Ponniasalan
Synthesis, characterization and antibacterial activity of bis thiourea derivatives
description A series of bisthiourea derivatives were succesfully synthesized by reaction of benzene-1, 4 dicarbonyl isothiocyanate intermediates and isophthaloyl dichloride, with a series of aromatic amine at ortho, meta and para position. The structure of synthesised compound characterized by infra-red spectroscopy (FTIR), 1H Nuclear magnetic resonances, and 13C Nuclear magnetic resonances. The synthesised compounds were screened for their antibacterial properties using Gram-negative bacteria Escherichia coli (E.coli) by using disc diffusion method. All of synthesized series showed negative results towards antibacterial activity.
format Final Year Project Report
author Jayakumar, Ponniasalan
author_facet Jayakumar, Ponniasalan
author_sort Jayakumar, Ponniasalan
title Synthesis, characterization and antibacterial activity of bis thiourea derivatives
title_short Synthesis, characterization and antibacterial activity of bis thiourea derivatives
title_full Synthesis, characterization and antibacterial activity of bis thiourea derivatives
title_fullStr Synthesis, characterization and antibacterial activity of bis thiourea derivatives
title_full_unstemmed Synthesis, characterization and antibacterial activity of bis thiourea derivatives
title_sort synthesis, characterization and antibacterial activity of bis thiourea derivatives
publisher Universiti Malaysia Sarawak, (UNIMAS)
publishDate 2015
url http://ir.unimas.my/id/eprint/11053/9/Synthesis%2C%20Characterization..%28fulltext%29.pdf
http://ir.unimas.my/id/eprint/11053/
_version_ 1770555374030553088
score 13.18916

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