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Amide as ligands for asymmetric transfer hydrogenation of prochiral ketones by ruthenium catalyst

MUCEET 2009 is organized by Malaysian Technical Universities Network (MTUN) comprising of Universiti Malaysia Perlis (UniMAP), Universiti Tun Hussein Onn (UTHM), Universiti Teknikal Melaka (UTeM) and Universiti Malaysia Pahang (UMP), 20th - 22nd June 2009 at M. S. Garden Hotel, Kuantan, Pahang.

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Main Authors: Wu, lihua, Zhou, zhongqiang, Kong, Yong Liew
Format: Working Paper
Language:English
Published: Universiti Malaysia Pahang (UMP) 2010
Subjects:
Amino amide hydrochlorides
Cinchonine
Sulfonamide
Asymmetric transfer hydrogenation (ATH)
Malaysian Technical Universities Conference on Engineering and Technology (MUCEET)
Online Access:http://dspace.unimap.edu.my/xmlui/handle/123456789/8670
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spelling my.unimap-86702010-08-13T09:17:30Z Amide as ligands for asymmetric transfer hydrogenation of prochiral ketones by ruthenium catalyst Wu, lihua Zhou, zhongqiang Kong, Yong Liew Amino amide hydrochlorides Cinchonine Sulfonamide Asymmetric transfer hydrogenation (ATH) Malaysian Technical Universities Conference on Engineering and Technology (MUCEET) MUCEET 2009 is organized by Malaysian Technical Universities Network (MTUN) comprising of Universiti Malaysia Perlis (UniMAP), Universiti Tun Hussein Onn (UTHM), Universiti Teknikal Melaka (UTeM) and Universiti Malaysia Pahang (UMP), 20th - 22nd June 2009 at M. S. Garden Hotel, Kuantan, Pahang. Chiral amide ligands were synthesized from L-proline and cinchonine and their application to asymmetric transfer hydrogenation of prochiral ketones was studied. Transfer hydrogen reaction catalyzed by proline based amino amide hydrochlorides was carried out in aqueous HCOONa while sulfonamide derived from cinchonin was carried out in iso-propanol containing NaOH using [RuCl2(p-cymene)] 2 as catalyst. The ATH of Chiral amino amide hydrochlorides reaction yielded excellent conversion rates of > 99% with good enantioselectivities (up to 76.9% ee) with water as solvent. The reaction of the substituted acetophenone showed that the enantioselectivity was not significantly affected by the type of substituent on aryl but also by alkyl. 2010-08-13T09:17:30Z 2010-08-13T09:17:30Z 2009-06-20 Working Paper http://hdl.handle.net/123456789/8670 en Proceedings of the Malaysian Technical Universities Conference on Engineering and Technology (MUCEET) 2009 Universiti Malaysia Pahang (UMP)
institution Universiti Malaysia Perlis
building UniMAP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Perlis
content_source UniMAP Library Digital Repository
url_provider http://dspace.unimap.edu.my/
language English
topic Amino amide hydrochlorides
Cinchonine
Sulfonamide
Asymmetric transfer hydrogenation (ATH)
Malaysian Technical Universities Conference on Engineering and Technology (MUCEET)
spellingShingle Amino amide hydrochlorides
Cinchonine
Sulfonamide
Asymmetric transfer hydrogenation (ATH)
Malaysian Technical Universities Conference on Engineering and Technology (MUCEET)
Wu, lihua
Zhou, zhongqiang
Kong, Yong Liew
Amide as ligands for asymmetric transfer hydrogenation of prochiral ketones by ruthenium catalyst
description MUCEET 2009 is organized by Malaysian Technical Universities Network (MTUN) comprising of Universiti Malaysia Perlis (UniMAP), Universiti Tun Hussein Onn (UTHM), Universiti Teknikal Melaka (UTeM) and Universiti Malaysia Pahang (UMP), 20th - 22nd June 2009 at M. S. Garden Hotel, Kuantan, Pahang.
format Working Paper
author Wu, lihua
Zhou, zhongqiang
Kong, Yong Liew
author_facet Wu, lihua
Zhou, zhongqiang
Kong, Yong Liew
author_sort Wu, lihua
title Amide as ligands for asymmetric transfer hydrogenation of prochiral ketones by ruthenium catalyst
title_short Amide as ligands for asymmetric transfer hydrogenation of prochiral ketones by ruthenium catalyst
title_full Amide as ligands for asymmetric transfer hydrogenation of prochiral ketones by ruthenium catalyst
title_fullStr Amide as ligands for asymmetric transfer hydrogenation of prochiral ketones by ruthenium catalyst
title_full_unstemmed Amide as ligands for asymmetric transfer hydrogenation of prochiral ketones by ruthenium catalyst
title_sort amide as ligands for asymmetric transfer hydrogenation of prochiral ketones by ruthenium catalyst
publisher Universiti Malaysia Pahang (UMP)
publishDate 2010
url http://dspace.unimap.edu.my/xmlui/handle/123456789/8670
_version_ 1643789295178219520
score 13.214268

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