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Development and characterization of Pennisetum Purpureum/pla biocomposite scaffold

Master of Science in Biomedical Engineering

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Bibliographic Details
Main Author: Radakisnin, Revati
Other Authors: Mohd Shukry, Abdul Majid, Ir. Dr.
Format: Thesis
Language:English
Published: Universiti Malaysia Perlis (UniMAP) 2017
Subjects:
Tissue scaffolds
Tissue engineering
Pennisetum purpureum
Articular cartilage
Biomedical engineering
Online Access:http://dspace.unimap.edu.my:80/xmlui/handle/123456789/77995
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spelling my.unimap-779952023-03-06T03:49:20Z Development and characterization of Pennisetum Purpureum/pla biocomposite scaffold Radakisnin, Revati Mohd Shukry, Abdul Majid, Ir. Dr. Tissue scaffolds Tissue engineering Pennisetum purpureum Articular cartilage Biomedical engineering Master of Science in Biomedical Engineering The mechanical, thermal, morphological properties and in vitro degradation study of a 3D porous Pennisetum purpureum (PP)/polylactic acid (PLA) based scaffold were investigated. In this study, a novel scaffold containing P. purpureum and PLA was produced using of the solvent casting and particulate leaching method. PLA composite with various P. purpureum contents (10 wt%, 20 wt%, and 30 wt%) were prepared and subsequently characterised. The morphologies, structures and thermal behaviours of the prepared composite scaffolds were characterised using field-emission scanning electron microscopy (FESEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA). The morphology was studied using FESEM; the scaffold possessed 70-200 μm-sized pores and had a greater porosity factor (99%) with a high level of interconnectivity. The mechanical properties and in vitro degradation of the developed porous scaffolds were further characterized. Compression tests were conducted to evaluate the compressive strength and modulus of the scaffolds, according to ASTM F451-95. The compression strength of the scaffolds was found to increase from 1.94 to 9.32 MPa, while the compressive modulus increased from 1.73 to 5.25 MPa as the fillers’ content increased from 0 wt% to 30 wt%. In this study, the synthesized composite scaffolds were immersed in a PBS solution at 37 °C for 40 days. Interestingly, the degradation rate was reduced for the PLA/PP20 scaffold, though insignificantly, this could be attributed to the improved mechanical properties and stronger fibre-matrix interface. Microstructure changes after degradation were observed using FESEM. The FESEM results indicated that a strong fibrematrix interface was formed in the PLA/PP20 scaffold, which reflected the addition of P. purpureum into PLA decreasing the degradation rate compared to in pure PLA scaffolds. From the results, it can be concluded that the properties of the highly porous P. purpureum/PLA scaffold developed in this study can be controlled and optimized. This can be used to facilitate the construction of implantable tissue-engineered cartilage. 2017 2023-03-06T03:47:54Z 2023-03-06T03:47:54Z Thesis http://dspace.unimap.edu.my:80/xmlui/handle/123456789/77995 en Universiti Malaysia Perlis (UniMAP) Universiti Malaysia Perlis (UniMAP) School of Mechatronic Engineering
institution Universiti Malaysia Perlis
building UniMAP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Perlis
content_source UniMAP Library Digital Repository
url_provider http://dspace.unimap.edu.my/
language English
topic Tissue scaffolds
Tissue engineering
Pennisetum purpureum
Articular cartilage
Biomedical engineering
spellingShingle Tissue scaffolds
Tissue engineering
Pennisetum purpureum
Articular cartilage
Biomedical engineering
Radakisnin, Revati
Development and characterization of Pennisetum Purpureum/pla biocomposite scaffold
description Master of Science in Biomedical Engineering
author2 Mohd Shukry, Abdul Majid, Ir. Dr.
author_facet Mohd Shukry, Abdul Majid, Ir. Dr.
Radakisnin, Revati
format Thesis
author Radakisnin, Revati
author_sort Radakisnin, Revati
title Development and characterization of Pennisetum Purpureum/pla biocomposite scaffold
title_short Development and characterization of Pennisetum Purpureum/pla biocomposite scaffold
title_full Development and characterization of Pennisetum Purpureum/pla biocomposite scaffold
title_fullStr Development and characterization of Pennisetum Purpureum/pla biocomposite scaffold
title_full_unstemmed Development and characterization of Pennisetum Purpureum/pla biocomposite scaffold
title_sort development and characterization of pennisetum purpureum/pla biocomposite scaffold
publisher Universiti Malaysia Perlis (UniMAP)
publishDate 2017
url http://dspace.unimap.edu.my:80/xmlui/handle/123456789/77995
_version_ 1772813087360942080
score 13.160551

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