Development and characterization of Pennisetum Purpureum/pla biocomposite scaffold
Master of Science in Biomedical Engineering
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Universiti Malaysia Perlis (UniMAP)
2017
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my.unimap-779952023-03-06T03:49:20Z Development and characterization of Pennisetum Purpureum/pla biocomposite scaffold Radakisnin, Revati Mohd Shukry, Abdul Majid, Ir. Dr. Tissue scaffolds Tissue engineering Pennisetum purpureum Articular cartilage Biomedical engineering Master of Science in Biomedical Engineering The mechanical, thermal, morphological properties and in vitro degradation study of a 3D porous Pennisetum purpureum (PP)/polylactic acid (PLA) based scaffold were investigated. In this study, a novel scaffold containing P. purpureum and PLA was produced using of the solvent casting and particulate leaching method. PLA composite with various P. purpureum contents (10 wt%, 20 wt%, and 30 wt%) were prepared and subsequently characterised. The morphologies, structures and thermal behaviours of the prepared composite scaffolds were characterised using field-emission scanning electron microscopy (FESEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA). The morphology was studied using FESEM; the scaffold possessed 70-200 μm-sized pores and had a greater porosity factor (99%) with a high level of interconnectivity. The mechanical properties and in vitro degradation of the developed porous scaffolds were further characterized. Compression tests were conducted to evaluate the compressive strength and modulus of the scaffolds, according to ASTM F451-95. The compression strength of the scaffolds was found to increase from 1.94 to 9.32 MPa, while the compressive modulus increased from 1.73 to 5.25 MPa as the fillers’ content increased from 0 wt% to 30 wt%. In this study, the synthesized composite scaffolds were immersed in a PBS solution at 37 °C for 40 days. Interestingly, the degradation rate was reduced for the PLA/PP20 scaffold, though insignificantly, this could be attributed to the improved mechanical properties and stronger fibre-matrix interface. Microstructure changes after degradation were observed using FESEM. The FESEM results indicated that a strong fibrematrix interface was formed in the PLA/PP20 scaffold, which reflected the addition of P. purpureum into PLA decreasing the degradation rate compared to in pure PLA scaffolds. From the results, it can be concluded that the properties of the highly porous P. purpureum/PLA scaffold developed in this study can be controlled and optimized. This can be used to facilitate the construction of implantable tissue-engineered cartilage. 2017 2023-03-06T03:47:54Z 2023-03-06T03:47:54Z Thesis http://dspace.unimap.edu.my:80/xmlui/handle/123456789/77995 en Universiti Malaysia Perlis (UniMAP) Universiti Malaysia Perlis (UniMAP) School of Mechatronic Engineering |
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Tissue scaffolds Tissue engineering Pennisetum purpureum Articular cartilage Biomedical engineering |
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Tissue scaffolds Tissue engineering Pennisetum purpureum Articular cartilage Biomedical engineering Radakisnin, Revati Development and characterization of Pennisetum Purpureum/pla biocomposite scaffold |
description |
Master of Science in Biomedical Engineering |
author2 |
Mohd Shukry, Abdul Majid, Ir. Dr. |
author_facet |
Mohd Shukry, Abdul Majid, Ir. Dr. Radakisnin, Revati |
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Thesis |
author |
Radakisnin, Revati |
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Radakisnin, Revati |
title |
Development and characterization of Pennisetum Purpureum/pla biocomposite scaffold |
title_short |
Development and characterization of Pennisetum Purpureum/pla biocomposite scaffold |
title_full |
Development and characterization of Pennisetum Purpureum/pla biocomposite scaffold |
title_fullStr |
Development and characterization of Pennisetum Purpureum/pla biocomposite scaffold |
title_full_unstemmed |
Development and characterization of Pennisetum Purpureum/pla biocomposite scaffold |
title_sort |
development and characterization of pennisetum purpureum/pla biocomposite scaffold |
publisher |
Universiti Malaysia Perlis (UniMAP) |
publishDate |
2017 |
url |
http://dspace.unimap.edu.my:80/xmlui/handle/123456789/77995 |
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1772813087360942080 |
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13.222552 |