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Synthesis of biodegradable polymeric nanoparticles by the mixture of organic/natural solvent

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Bibliographic Details
Main Author: Nawananthinye, Sinnathamby
Other Authors: Rahimah, Othman, Dr.
Format: Learning Object
Language:English
Published: Universiti Malaysia Perlis (UniMAP) 2021
Subjects:
Nanoparticles (NPs)
Solvent
Polymers
Organic solvent
Online Access:http://dspace.unimap.edu.my:80/xmlui/handle/123456789/73479
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spelling my.unimap-734792022-01-18T08:07:21Z Synthesis of biodegradable polymeric nanoparticles by the mixture of organic/natural solvent Nawananthinye, Sinnathamby Rahimah, Othman, Dr. School of Bioprocess Engineering Nanoparticles (NPs) Solvent Polymers Organic solvent Access is limited to UniMAP community. The aim of this study was to develop a new strategy of producing biodegradable engineered functional polymeric nanoparticles (NPs) using a mixture of organic/natural solvents. The polymeric NPs were prepared from biodegradable polymer such as poly-ε- caprolactone (PCL) within size range between 10-1000 nm which capable to dissolve and, encapsulate the active ingredients to a nanoparticle matrix. The main advantage of NPs is to deliver the drug with the active ingredient to a specific targeted area to cure disease such as cancer or tumour in human body. The solvent plays an important role in solvent displacement (nanoprecipitation) method. Hansen Solubility Parameter (HSP) can be used to determine a distance between two molecules (Ra) which is to identify the influence of mixed solvents on the nanoparticles synthesis. The characterise the physiochemical properties of formulated nanoparticles was determined by using Scanning Electron Microscope (SEM), and Fourier Transfer Infrared Spectroscopy (FTIR) SEM used to determine the particle size and also morphology structure of the particles and the particle must have smooth surface and spherical in shape. Due to the higher affinity of solvent for water and the higher its solubility in to the aqueous phase and smaller Ra value produce smaller polymeric NPs. 2021 2022-01-18T08:07:21Z 2022-01-18T08:07:21Z 2017-06 Learning Object http://dspace.unimap.edu.my:80/xmlui/handle/123456789/73479 en Universiti Malaysia Perlis (UniMAP)
institution Universiti Malaysia Perlis
building UniMAP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Perlis
content_source UniMAP Library Digital Repository
url_provider http://dspace.unimap.edu.my/
language English
topic Nanoparticles (NPs)
Solvent
Polymers
Organic solvent
spellingShingle Nanoparticles (NPs)
Solvent
Polymers
Organic solvent
Nawananthinye, Sinnathamby
Synthesis of biodegradable polymeric nanoparticles by the mixture of organic/natural solvent
description Access is limited to UniMAP community.
author2 Rahimah, Othman, Dr.
author_facet Rahimah, Othman, Dr.
Nawananthinye, Sinnathamby
format Learning Object
author Nawananthinye, Sinnathamby
author_sort Nawananthinye, Sinnathamby
title Synthesis of biodegradable polymeric nanoparticles by the mixture of organic/natural solvent
title_short Synthesis of biodegradable polymeric nanoparticles by the mixture of organic/natural solvent
title_full Synthesis of biodegradable polymeric nanoparticles by the mixture of organic/natural solvent
title_fullStr Synthesis of biodegradable polymeric nanoparticles by the mixture of organic/natural solvent
title_full_unstemmed Synthesis of biodegradable polymeric nanoparticles by the mixture of organic/natural solvent
title_sort synthesis of biodegradable polymeric nanoparticles by the mixture of organic/natural solvent
publisher Universiti Malaysia Perlis (UniMAP)
publishDate 2021
url http://dspace.unimap.edu.my:80/xmlui/handle/123456789/73479
_version_ 1729704639149899776
score 13.214268

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