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The effect of organic surfactant for stabilizing engineered functional pharmaceutical biodegradable polymeric nanoparticles

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Bibliographic Details
Main Author: Azman, Muhamad @ Muhamad Nor
Other Authors: School of Bioprocess Engineering
Format: Other
Language:English
Published: Universiti Malaysia Perlis (UniMAP) 2022
Subjects:
Nanoparticles (NPs)
Biodegradable polymeric nanoparticles (NPs)
Polymers
Online Access:http://dspace.unimap.edu.my:80/xmlui/handle/123456789/73355
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spelling my.unimap-733552022-01-13T04:08:21Z The effect of organic surfactant for stabilizing engineered functional pharmaceutical biodegradable polymeric nanoparticles Azman, Muhamad @ Muhamad Nor School of Bioprocess Engineering Nanoparticles (NPs) Biodegradable polymeric nanoparticles (NPs) Polymers Access is limited to UniMAP community. Biodegradable polymeric nanoparticles (NPs) are produced via nanoprecipitation method also known as solvent displacement method that involved chemical reaction of organic phase to aqueous phase. The objectives of this study are to study the optimum condition of some parameters for the biodegradable polymeric nanoparticles (NPs) production by using design of experiment (DOE) approach. The recommended optimized condition that was suggested by DOE approached were; volume ratio of organic phase to aqueous phase at 10, agitation speed on aqueous phase at 1000 rpm and polymer concentration at 1 mg/mL. Under this operating condition, the model was predicted to achieve lower particle size in polymeric NPs which is at 398.126 nm. Then, the suggested optimum process parameters were applied for stabilization with the addition of polyvinylpyrrolidone (PVP) in the aqueous phase. Observation based on their color change was done for one month. The surfactant ratio was fixed at 1 wt%. The effectiveness and physico-chemical properties of functional particles in production of biodegradable polymeric NPs were investigated by using Scanning Electron Microscopic (SEM) and Fourier Transform Infrared (FTIR). 2022-01-13T04:08:21Z 2022-01-13T04:08:21Z 2017-06 Other http://dspace.unimap.edu.my:80/xmlui/handle/123456789/73355 en Universiti Malaysia Perlis (UniMAP)
institution Universiti Malaysia Perlis
building UniMAP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Perlis
content_source UniMAP Library Digital Repository
url_provider http://dspace.unimap.edu.my/
language English
topic Nanoparticles (NPs)
Biodegradable polymeric nanoparticles (NPs)
Polymers
spellingShingle Nanoparticles (NPs)
Biodegradable polymeric nanoparticles (NPs)
Polymers
Azman, Muhamad @ Muhamad Nor
The effect of organic surfactant for stabilizing engineered functional pharmaceutical biodegradable polymeric nanoparticles
description Access is limited to UniMAP community.
author2 School of Bioprocess Engineering
author_facet School of Bioprocess Engineering
Azman, Muhamad @ Muhamad Nor
format Other
author Azman, Muhamad @ Muhamad Nor
author_sort Azman, Muhamad @ Muhamad Nor
title The effect of organic surfactant for stabilizing engineered functional pharmaceutical biodegradable polymeric nanoparticles
title_short The effect of organic surfactant for stabilizing engineered functional pharmaceutical biodegradable polymeric nanoparticles
title_full The effect of organic surfactant for stabilizing engineered functional pharmaceutical biodegradable polymeric nanoparticles
title_fullStr The effect of organic surfactant for stabilizing engineered functional pharmaceutical biodegradable polymeric nanoparticles
title_full_unstemmed The effect of organic surfactant for stabilizing engineered functional pharmaceutical biodegradable polymeric nanoparticles
title_sort effect of organic surfactant for stabilizing engineered functional pharmaceutical biodegradable polymeric nanoparticles
publisher Universiti Malaysia Perlis (UniMAP)
publishDate 2022
url http://dspace.unimap.edu.my:80/xmlui/handle/123456789/73355
_version_ 1724610033651548160
score 13.222552

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