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Production of Hydroxyapatite (HAp) nanoparticles by Sol-Gel method

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Main Author: Ang, Fong Chuan
Other Authors: School of Bioprocess Engineering
Format: Other
Language:English
Published: Universiti Malaysia Perlis (UniMAP) 2022
Subjects:
Nanoparticles
Hydroxyapatite (HAp)
Sol-gel method
Calcium phosphates
Online Access:http://dspace.unimap.edu.my:80/xmlui/handle/123456789/73346
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spelling my.unimap-733462022-01-13T01:58:43Z Production of Hydroxyapatite (HAp) nanoparticles by Sol-Gel method Ang, Fong Chuan School of Bioprocess Engineering Nanoparticles Hydroxyapatite (HAp) Sol-gel method Calcium phosphates Access is limited to UniMAP community. Hydroxyapatite (HAp) with chemical formula of Ca₁₀(PO₄)₆(OH)₂ is one of well -known bioceramic from calcium phosphate (CaP) family because of the similarities between natural bone minerals and posseses the biological properties of biocompatibility and bioactivity make it important for artificial bone substitute. Sol-gel method is much more preferred with the advantage of possibility of a strict control of process parameters. The synthesis routes using precursor of calcium nitrate tetrahydrate (Ca(NO₃)₂∙H₂O) and phosphoric pentoxide (P₂O₅) with different stirring speed from 100 rpm to 500 rpm, aging time from 1 hour to 5 hours and sintering temperature from 600°C to 800°C. Characterisation of HAp is carried out using FTIR for functional groups identification which were hydroxyl (3570 cm-1) and phosphate (1087 cm-1), XRD for phase composition showed the sharp peaks at angle 31.8o and 26o proved the formation of HAp and calculate crystallite size using Scherrer’s formula had calculated the range of size from 28.621nm to 34.726 nm and SEM for particle morphology observed that highly agglomerated of particle HAp. In order to optimize the process conditions, Response Surface Methodology (RSM) was employed by choosing Central Composite Design (CCD) has optimized the conditions of stirring rate of 300 rpm, 3 hours aging time and 700°C of sintering temperature, the resultant size was 32.5126nm. 2022-01-13T01:58:43Z 2022-01-13T01:58:43Z 2017-06 Other http://dspace.unimap.edu.my:80/xmlui/handle/123456789/73346 en Universiti Malaysia Perlis (UniMAP)
institution Universiti Malaysia Perlis
building UniMAP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Perlis
content_source UniMAP Library Digital Repository
url_provider http://dspace.unimap.edu.my/
language English
topic Nanoparticles
Hydroxyapatite (HAp)
Sol-gel method
Calcium phosphates
spellingShingle Nanoparticles
Hydroxyapatite (HAp)
Sol-gel method
Calcium phosphates
Ang, Fong Chuan
Production of Hydroxyapatite (HAp) nanoparticles by Sol-Gel method
description Access is limited to UniMAP community.
author2 School of Bioprocess Engineering
author_facet School of Bioprocess Engineering
Ang, Fong Chuan
format Other
author Ang, Fong Chuan
author_sort Ang, Fong Chuan
title Production of Hydroxyapatite (HAp) nanoparticles by Sol-Gel method
title_short Production of Hydroxyapatite (HAp) nanoparticles by Sol-Gel method
title_full Production of Hydroxyapatite (HAp) nanoparticles by Sol-Gel method
title_fullStr Production of Hydroxyapatite (HAp) nanoparticles by Sol-Gel method
title_full_unstemmed Production of Hydroxyapatite (HAp) nanoparticles by Sol-Gel method
title_sort production of hydroxyapatite (hap) nanoparticles by sol-gel method
publisher Universiti Malaysia Perlis (UniMAP)
publishDate 2022
url http://dspace.unimap.edu.my:80/xmlui/handle/123456789/73346
_version_ 1724610032341876736
score 13.214268

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