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Analysis of MDA-MB-231 cancer cell Dielectrophoretic response

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Main Authors: Mohd Anuar, Md Ali, Aminuddin, Ahmad Kayani, Burhanuddin, Yeop Majlis
Other Authors: burhan@ukm.edu.my
Format: Article
Language:English
Published: Universiti Malaysia Perlis (UniMAP) 2021
Subjects:
Dielectrophoresis
Dielectrophoretic force
Cancer cells
MDA-MB-231
Online Access:http://dspace.unimap.edu.my:80/xmlui/handle/123456789/69584
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spelling my.unimap-695842021-02-08T04:07:54Z Analysis of MDA-MB-231 cancer cell Dielectrophoretic response Mohd Anuar, Md Ali Aminuddin, Ahmad Kayani Burhanuddin, Yeop Majlis burhan@ukm.edu.my Dielectrophoresis Dielectrophoretic force Cancer cells MDA-MB-231 Link to publisher's homepage at http://ijneam.unimap.edu.my Dielectrophoresis (DEP) is a phenomenon where a neutral particle can be either attracted to (pDEP) or repelled away from (nDEP) specific regions with highest electric field gradient. In previous work, we demonstrated the simulation and experimental work with yeast cell suspended in deionized water, where the result showed that yeast cells experience linear and rotational motion under DEP. In this work, we extend our work into the study of cancer cells, specifically MDA-MB-231 cell. While no DEP response is predicted at higher DMEM concentration, for MDA-MB-231 cells suspended in diluted DMEM (1%), the simulation shows that within frequency range of 1 kHz to 10 GHz, the cross-over frequency located at 80 kHz and 120 MHz, with cell demonstrates pDEP at frequency range between those two, while nDEP is at both frequency ranges less than 80 kHz and higher than 120 MHz. The following experimental work justify the simulation result, with the cell exhibits nDEP at 50 kHz, while pDEP is observed at 100, 200 and 500 kHz, among those selected frequencies. Due to substantial difference between the cell mass, the response time is hugely different with cancer cell shown significant reduction, however, the quantification is expected at future work. 2021-02-08T04:07:54Z 2021-02-08T04:07:54Z 2020-12 Article International Journal of Nanoelectronics and Materials, vol.13(Special Issue), 2020, pages 243-248 1985-5761 (Printed) 1997-4434 (Online) http://dspace.unimap.edu.my:80/xmlui/handle/123456789/69584 en NANOSYM, 2019; Universiti Malaysia Perlis (UniMAP)
institution Universiti Malaysia Perlis
building UniMAP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Perlis
content_source UniMAP Library Digital Repository
url_provider http://dspace.unimap.edu.my/
language English
topic Dielectrophoresis
Dielectrophoretic force
Cancer cells
MDA-MB-231
spellingShingle Dielectrophoresis
Dielectrophoretic force
Cancer cells
MDA-MB-231
Mohd Anuar, Md Ali
Aminuddin, Ahmad Kayani
Burhanuddin, Yeop Majlis
Analysis of MDA-MB-231 cancer cell Dielectrophoretic response
description Link to publisher's homepage at http://ijneam.unimap.edu.my
author2 burhan@ukm.edu.my
author_facet burhan@ukm.edu.my
Mohd Anuar, Md Ali
Aminuddin, Ahmad Kayani
Burhanuddin, Yeop Majlis
format Article
author Mohd Anuar, Md Ali
Aminuddin, Ahmad Kayani
Burhanuddin, Yeop Majlis
author_sort Mohd Anuar, Md Ali
title Analysis of MDA-MB-231 cancer cell Dielectrophoretic response
title_short Analysis of MDA-MB-231 cancer cell Dielectrophoretic response
title_full Analysis of MDA-MB-231 cancer cell Dielectrophoretic response
title_fullStr Analysis of MDA-MB-231 cancer cell Dielectrophoretic response
title_full_unstemmed Analysis of MDA-MB-231 cancer cell Dielectrophoretic response
title_sort analysis of mda-mb-231 cancer cell dielectrophoretic response
publisher Universiti Malaysia Perlis (UniMAP)
publishDate 2021
url http://dspace.unimap.edu.my:80/xmlui/handle/123456789/69584
_version_ 1698698625913192448
score 13.222552

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