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Design and Optimize Solid Microneedle using Genetic Algorithm

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Main Authors: Nurul Fatihah, Zaharin, Marni Azira, Markom, Erdy Sulino, Mohd Muslim Tan, Norhayati, Sabani
Other Authors: marni@unimap.edu.my
Format: Article
Language:English
Published: IOP Publishing 2020
Subjects:
Microneedle
Genetic algorithm
Transdermal drug delivery (TTD)
Online Access:http://dspace.unimap.edu.my:80/xmlui/handle/123456789/69016
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spelling my.unimap-690162020-12-16T04:37:52Z Design and Optimize Solid Microneedle using Genetic Algorithm Nurul Fatihah, Zaharin Marni Azira, Markom Erdy Sulino, Mohd Muslim Tan Norhayati, Sabani marni@unimap.edu.my Microneedle Genetic algorithm Transdermal drug delivery (TTD) Link to publisher's homepage at https://iopscience.iop.org/ Microneedle is an example of Transdermal drug delivery (TTD) device. It is known for eliminating pain and inconvenient intravenous injections. This study presents a work on design microneedle and optimize the designs using Genetic Algorithm (GA). At first, a few solid microneedles are designed with difference parameters, and the considered parameters involve are shape of the needle, materials, size of array, base of microneedle, height of microneedle and number of needles on the microneedle’s array base. The microneedle is designed to meet the output requirement which are the total deformation and equivalent stress. Pressure on the tip and size of microneedle base are set to be constant which are 3.18 MPa and 2500 µm x 2500 µm x 50 µm, respectively. Then, optimisation process is conducted on the designs using Genetic Algorithm. Based on the optimisation results, it showed that the optimum structure for the studied microneedles is canonical type, diameter and needle height are 500 µm and 500 µm, respectively, PVA material and involve with 3 number of needles. The results showed that GA is capable to achieve the output requirement and able to optimize the parameter of the microneedle structure. 2020-12-16T04:37:52Z 2020-12-16T04:37:52Z 2019 Article Journal of Physics: Conference Series, vol.1372, 2019, 6 pages 1742-6588 (print) 1742-6596 (online) http://dspace.unimap.edu.my:80/xmlui/handle/123456789/69016 https://iopscience.iop.org/issue/1742-6596/1372/1 en International Conference on Biomedical Engineering (ICoBE); IOP Publishing
institution Universiti Malaysia Perlis
building UniMAP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Perlis
content_source UniMAP Library Digital Repository
url_provider http://dspace.unimap.edu.my/
language English
topic Microneedle
Genetic algorithm
Transdermal drug delivery (TTD)
spellingShingle Microneedle
Genetic algorithm
Transdermal drug delivery (TTD)
Nurul Fatihah, Zaharin
Marni Azira, Markom
Erdy Sulino, Mohd Muslim Tan
Norhayati, Sabani
Design and Optimize Solid Microneedle using Genetic Algorithm
description Link to publisher's homepage at https://iopscience.iop.org/
author2 marni@unimap.edu.my
author_facet marni@unimap.edu.my
Nurul Fatihah, Zaharin
Marni Azira, Markom
Erdy Sulino, Mohd Muslim Tan
Norhayati, Sabani
format Article
author Nurul Fatihah, Zaharin
Marni Azira, Markom
Erdy Sulino, Mohd Muslim Tan
Norhayati, Sabani
author_sort Nurul Fatihah, Zaharin
title Design and Optimize Solid Microneedle using Genetic Algorithm
title_short Design and Optimize Solid Microneedle using Genetic Algorithm
title_full Design and Optimize Solid Microneedle using Genetic Algorithm
title_fullStr Design and Optimize Solid Microneedle using Genetic Algorithm
title_full_unstemmed Design and Optimize Solid Microneedle using Genetic Algorithm
title_sort design and optimize solid microneedle using genetic algorithm
publisher IOP Publishing
publishDate 2020
url http://dspace.unimap.edu.my:80/xmlui/handle/123456789/69016
_version_ 1698698544114827264
score 13.214268

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