Histopathological changes associated with oxidative stress induced by electromagnetic waves in rats' ovarian and uterine tissues
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Wolters Kluwer Medknow Publications
2020
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my.unimap-687262020-11-16T04:23:01Z Histopathological changes associated with oxidative stress induced by electromagnetic waves in rats' ovarian and uterine tissues Ali S.H., Alchalabi Hasliza, Rahim Erkihun, Aklilu Imad I., Al-Sultan Abd Rahman, Aziz Mohd Fareq, Abd Malek Suzanna, H. Ronald Mohd Azam, Khan alisaeedchalaby@yahoo.com Histopathological changes Female sex organs Oxidative stress Electromagnetic radiation Link to publisher's homepage at http://www.apjr.net/aboutus.asp Objective To evaluate the histopathological changes in ovarian and uterine tissues associated with oxidative stress induced by electromagnetic waves. Methods Thirty female Sprague Dawley of 180 g body weight and 3 months old were used in the experimental work. Animals were divided into control and two experimental groups. Experimental groups were exposed to 1 800 MHz Global System for Mobile Communication radiofrequency radiation emitted by a signal generator for 2 h per day for 30 and 60 d, respectively. Following exposure, serum, ovaries and uteri were collected for biochemical and histopathological investigations. Results Biochemical analysis showed alterations in oxidative stress parameters in both ovaries and uteri tissues in comparison to control group. The histopathological changes were more prominent in experimental groups, in the ovary were included vacuolation in interstitial, granulosa, luteal cells and ooplasm. Other histopathological changes are disorientation of corona radiata, disruption and thinning of the zona pellucida. Cellular nucleus changes similar to fragmentation of the nucleus indicate the start of a degeneration process at Graafian follicles as well as micronuclei formation in oocyte nucleus and in some luteal cells. Histopathological changes in uterine tissue confined to increase height of luminal epithelium cells, sever apoptosis of glandular and luminal epithelium cells, and sever eosinophils, polymorphonucleocyte lymphocytes and macrophage's infiltration in myometrium and endometrium layers. Vascular congestion points out for the existence of inflammatory response changes in the endometrium. Conclusion Results executed that the potential alteration of antioxidant capacity may contribute to endometrial oxidative damage that could be related to pathogenesis and progression of endometritis. 2020-11-16T04:23:01Z 2020-11-16T04:23:01Z 2016 Article Asian Pacific Journal of Reproduction, vol.5(4), 2016, pages 301-310 2305-0500 (print) 2305-0519 (online) http://dspace.unimap.edu.my:80/xmlui/handle/123456789/68726 https://doi.org/10.1016/j.apjr.2016.06.008 en Wolters Kluwer Medknow Publications |
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Malaysia |
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Universiti Malaysia Perlis |
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| language |
English |
| topic |
Histopathological changes Female sex organs Oxidative stress Electromagnetic radiation |
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Histopathological changes Female sex organs Oxidative stress Electromagnetic radiation Ali S.H., Alchalabi Hasliza, Rahim Erkihun, Aklilu Imad I., Al-Sultan Abd Rahman, Aziz Mohd Fareq, Abd Malek Suzanna, H. Ronald Mohd Azam, Khan Histopathological changes associated with oxidative stress induced by electromagnetic waves in rats' ovarian and uterine tissues |
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Link to publisher's homepage at http://www.apjr.net/aboutus.asp |
| author2 |
alisaeedchalaby@yahoo.com |
| author_facet |
alisaeedchalaby@yahoo.com Ali S.H., Alchalabi Hasliza, Rahim Erkihun, Aklilu Imad I., Al-Sultan Abd Rahman, Aziz Mohd Fareq, Abd Malek Suzanna, H. Ronald Mohd Azam, Khan |
| format |
Article |
| author |
Ali S.H., Alchalabi Hasliza, Rahim Erkihun, Aklilu Imad I., Al-Sultan Abd Rahman, Aziz Mohd Fareq, Abd Malek Suzanna, H. Ronald Mohd Azam, Khan |
| author_sort |
Ali S.H., Alchalabi |
| title |
Histopathological changes associated with oxidative stress induced by electromagnetic waves in rats' ovarian and uterine tissues |
| title_short |
Histopathological changes associated with oxidative stress induced by electromagnetic waves in rats' ovarian and uterine tissues |
| title_full |
Histopathological changes associated with oxidative stress induced by electromagnetic waves in rats' ovarian and uterine tissues |
| title_fullStr |
Histopathological changes associated with oxidative stress induced by electromagnetic waves in rats' ovarian and uterine tissues |
| title_full_unstemmed |
Histopathological changes associated with oxidative stress induced by electromagnetic waves in rats' ovarian and uterine tissues |
| title_sort |
histopathological changes associated with oxidative stress induced by electromagnetic waves in rats' ovarian and uterine tissues |
| publisher |
Wolters Kluwer Medknow Publications |
| publishDate |
2020 |
| url |
http://dspace.unimap.edu.my:80/xmlui/handle/123456789/68726 |
| _version_ |
1698698502039666688 |
| score |
13.214268 |